Protein Info for GFF4047 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: DNA polymerase III epsilon subunit (EC 2.7.7.7)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 246 TIGR00573: exonuclease, DNA polymerase III, epsilon subunit family" amino acids 9 to 228 (220 residues), 322.5 bits, see alignment E=1.2e-100 TIGR01406: DNA polymerase III, epsilon subunit" amino acids 10 to 245 (236 residues), 315.2 bits, see alignment E=2.6e-98 PF00929: RNase_T" amino acids 12 to 178 (167 residues), 144.2 bits, see alignment E=2.7e-46

Best Hits

Swiss-Prot: 100% identical to DPO3E_SALTY: DNA polymerase III subunit epsilon (dnaQ) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K02342, DNA polymerase III subunit epsilon [EC: 2.7.7.7] (inferred from 100% identity to set:SEN0266)

MetaCyc: 93% identical to DNA polymerase III subunit epsilon (Escherichia coli K-12 substr. MG1655)
3.1.11.-

Predicted SEED Role

"DNA polymerase III epsilon subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (246 amino acids)

>GFF4047 DNA polymerase III epsilon subunit (EC 2.7.7.7) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MTDMSTAITRQIVLDTETTGMNQIGAHYEGHKIIEIGAVEVINRRLTGNNFHVYLKPDRL
VDPEAFGVHGIADEFLLDKPVFADVVDEFLDYIRGAELVIHNASFDIGFMDYEFGLLKRD
IPKTNTFCKVTDSLALARKMFPGKRNSLDALCSRYEIDNSKRTLHGALLDAQILAEVYLA
MTGGQTSMTFAMEGETQRQQGEATIQRIVRQASRLRVVFASEEELAAHESRLDLVQKKGG
SCLWRA