Protein Info for GFF4046 in Variovorax sp. SCN45

Annotation: Cobalt/zinc/cadmium efflux RND transporter, transmembrane protein CzcA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1082 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 346 to 363 (18 residues), see Phobius details amino acids 368 to 387 (20 residues), see Phobius details amino acids 395 to 417 (23 residues), see Phobius details amino acids 451 to 470 (20 residues), see Phobius details amino acids 482 to 508 (27 residues), see Phobius details amino acids 529 to 555 (27 residues), see Phobius details amino acids 898 to 917 (20 residues), see Phobius details amino acids 924 to 943 (20 residues), see Phobius details amino acids 949 to 974 (26 residues), see Phobius details amino acids 998 to 1018 (21 residues), see Phobius details amino acids 1027 to 1050 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1065 (1065 residues), 1743.2 bits, see alignment E=0 PF00873: ACR_tran" amino acids 5 to 1054 (1050 residues), 1173.3 bits, see alignment E=0

Best Hits

MetaCyc: 72% identical to cation efflux system protein (Pseudomonas putida KT2440)
RXN1G01-61; TRANS-RXN0-200; TRANS-RXN0-244

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1082 amino acids)

>GFF4046 Cobalt/zinc/cadmium efflux RND transporter, transmembrane protein CzcA (Variovorax sp. SCN45)
MFERIIRFAIEQRWLILLAVVAMAGLGVYNYQKLPIDAVPDITNVQVQINTGAPGYSPLE
TEQRVTFPIETVMAGLPGLLQTRSLSRYGLSQVTVIFKDGTDVYFARQLVNERLQSASGE
MPEGVHPQVGPISTGLGEIYLWTVEAKDGAKKPDGTPYTSTDLREIQDWIIKPQLRNVAG
VTEINSIGGYEKQYQIAPIPEKLSAYGLSMADVVKALERNNTNVGAGYIERRGEQYLIRA
PGQARGVEDLRNIILSSNGSTPVRVRDVAEVGIGKELRTGAATDNGREVVLGTVFMLIGE
NSRIVSQAVAKKMADINRTLPEGVEAITVYDRTVLVDKAIATVKKNLLEGAVLVIVVLFL
FLGNMRAAVITAMVIPLSMLFTFTGMVNQKVSANLMSLGALDFGIIIDGAVVIVENCVRR
LAHAQHRHGRPLTRKERFHEVFAASQEARRALLFGQLIIMIVYLPIFALTGVEGKMFHPM
ALTVVIALLGAMILSVTFIPAAVALFIGKKVSEKENRLMGWAKKAYEPLLVRVLEAKAVV
LTVAGIAVVLAGLLATRLGSEFIPNLNEGDFAVQALRIPGTSLSQSVQMQQQLERTLKEK
FPEIDRIFARTGTAEIASDPMPPNISDAYVMLKPVDQWPEPRRTRQEVVQAVQKEVSKIP
GNNYEFSQPIQLRFNELVSGVRADVAVKVFGDDMDVLNKTAREIEGVLKSISGAAEVNVE
QTTGLPMLTVNIDRDKATRYGLNIADVQDTIATAIGGRNAGTLFEGDRRFDIVVRLPDNV
RGDLEAIKRLPIALPASSAAADVVGATSVAGAGANAARVNFIPLGEVATLELAPGPNQVS
REDGKRRIVVSANVRGRDLGSFVSEAAGALDSQVKVPTGYWTTWGGQFENLQSATKRLQI
VVPVALLLVFTLLFAMFGNMKDGLIVFTGIPFALTGGILALWLRDIPLSITAAVGFIALS
GVAVLNGLVMISFIRNLREGGASLDHAIHEGALTRLRPVLMTALVASLGFVPMAIATGTG
AEVQQPLATVVIGGILSSTALTLLVLPVLYRLAHGRDEEEAVFNEAQKQAALEHEIPPQP
AA