Protein Info for GFF4037 in Variovorax sp. SCN45

Annotation: CzcABC family efflux RND transporter, transmembrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1041 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 339 to 356 (18 residues), see Phobius details amino acids 363 to 383 (21 residues), see Phobius details amino acids 390 to 414 (25 residues), see Phobius details amino acids 440 to 460 (21 residues), see Phobius details amino acids 473 to 499 (27 residues), see Phobius details amino acids 530 to 549 (20 residues), see Phobius details amino acids 864 to 884 (21 residues), see Phobius details amino acids 892 to 915 (24 residues), see Phobius details amino acids 921 to 943 (23 residues), see Phobius details amino acids 964 to 983 (20 residues), see Phobius details amino acids 995 to 1018 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1031 (1031 residues), 1086 bits, see alignment E=0 PF00873: ACR_tran" amino acids 7 to 1019 (1013 residues), 966.5 bits, see alignment E=1.5e-294 PF03176: MMPL" amino acids 259 to 498 (240 residues), 22.8 bits, see alignment E=4.1e-09

Best Hits

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 75% identity to app:CAP2UW1_4548)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1041 amino acids)

>GFF4037 CzcABC family efflux RND transporter, transmembrane protein (Variovorax sp. SCN45)
MLNALVDASLRYKVLVLVFFAVLVGLGVQAFRNVPVDAFPDVTPVQVNIYTESPGLAAED
VEKLLTTPIEGAMAGLPGVEEVRSVSLFGLSYVGVYFKDDVDIYFARRLVGEKLQEAKGR
LPQGYGEPVLGPNSSGLGQVFWYTVESEDKKMSTMDLRTLHDWTVRLILRTAPGVDDIVS
WGGEQKQFQVQIDPRKLIQYSVSFKEVMERLTANNKQVGGQSINLGAEQFLVRGLGLVGT
TKDIEQIVIAERNGAPVYVRNVAQVKEAPAPRFGAVTRDGKEAVLGIALARVNENAKNVV
DAVKAKLAVAQAALPKGVTLQPVYDRTELVKKALNTAESSLVEGAILVAVILFLFLGEFR
SAIVVVITLPMAMLIAFILMQQFGVSANLMSLAGLAIGTGMMVDGAVVMVENAFRLLAHA
KESGKPIQKTHLILEAAREVVNPIAFAILIIIVVFLPLFSLTGLEGKLFKPMAYTITFAM
AGSLLLSLTLVPVLAAMILKPKEEKDTFLVRRAKRIYLPLLDWALERKRLVVGSAIVLLL
ASLALFPFLGKEFMPQLQEGTIQFRVTGIPSTSLDESIRVSNEVSAALRKQFPQVRSVLA
TIGRAEGGETTDVNYMELNLDTKPAEEWPEKISYGKLASDMQEALEKVVPTVVFGATQPI
QSRVEELISGVRATLALKLYGEDLATLDRLTGKIQGVLGKIPGIADLSAEANKGKPQLII
KVNRDAAARYGINADEILEVVQSGIGGSAVSTLIDGTKRFEIAVRLSDEFRVSPAAIASI
PIRTGGGALVPFSQVASIELDEGYSFIRRESLQRYSVLQMDVKGRDVDSFVKEADTQLKA
QVELPTGYWIEWGGSFENQQRAMARLGVIVPLTIGLIFILLYTAFNSVRHATLIIANVPF
AIIGGIVGLFVSGQYLSVPSAIGFIAVFGVAMLNGIVMVTFLNDLRRQGLPIREAVQQGA
ALRLRPVLMTASVAILGLIPMLLSTGVGAETQRPLATVVVGGLFTSTALTLLILPLMYEW
AEQRAERRKAKTEEILEGETP