Protein Info for GFF4036 in Hydrogenophaga sp. GW460-11-11-14-LB1
Annotation: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 46% identical to FUSA3_GIBZE: Aminotransferase FGSG_17085 (FGRAMPH1_01T09365) from Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
KEGG orthology group: K00837, [EC: 2.6.1.-] (inferred from 77% identity to rfr:Rfer_1041)Predicted SEED Role
"Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)" in subsystem Biotin biosynthesis (EC 2.6.1.62)
MetaCyc Pathways
- biotin biosynthesis I (13/15 steps found)
- biotin biosynthesis from 8-amino-7-oxononanoate I (4/4 steps found)
KEGG Metabolic Maps
- Aminophosphonate metabolism
- Arginine and proline metabolism
- Biotin metabolism
- Caprolactam degradation
- Lysine biosynthesis
- Lysine degradation
- Methionine metabolism
- Nucleotide sugars metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.6.1.-, 2.6.1.62
Use Curated BLAST to search for 2.6.1.- or 2.6.1.62
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (429 amino acids)
>GFF4036 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) (Hydrogenophaga sp. GW460-11-11-14-LB1) MPFAVSGQGITLTDQAGKSYLDASGGAAVSCLGHGHPDVVAAMHAQIDQLAYAHTSFFTT EVAEELADVLIDSAPAGMSHVYFVSGGSEAVEAALKMARQYFVEIGQSQRRHFIARRQSY HGNTLGALAVGGNAWRREQFKPLLIDVTHVSPCYEYRDRREGESAEQYGQRLVDELSDAI DRLGGENVMAFVAETVGGATAGVLTAVPGYFKGVRELCDRHGILLILDEVMCGMGRTGTL HACEQEGVVPDLMTIAKGLGGGYQPIGAVLAQGRVVDAFRQGSGLFQHGHTYLGHAIACA AALAVQRVIQRDGLLAQVRERGQLLQSLLQQAFGGHPHVGDIRGRGLFWGIELVADRGSQ QWFDPARKLHARIKSEAMAGGLMVYPMGGTVDGRCGDHVLLAPPFISTPDELEQIVARLA GAIDRAVAA