Protein Info for GFF4033 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Probable transmembrane drug efflux protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1053 transmembrane" amino acids 32 to 51 (20 residues), see Phobius details amino acids 354 to 375 (22 residues), see Phobius details amino acids 395 to 416 (22 residues), see Phobius details amino acids 422 to 446 (25 residues), see Phobius details amino acids 463 to 484 (22 residues), see Phobius details amino acids 496 to 521 (26 residues), see Phobius details amino acids 559 to 579 (21 residues), see Phobius details amino acids 894 to 913 (20 residues), see Phobius details amino acids 922 to 942 (21 residues), see Phobius details amino acids 948 to 969 (22 residues), see Phobius details amino acids 997 to 1016 (20 residues), see Phobius details amino acids 1022 to 1046 (25 residues), see Phobius details PF00873: ACR_tran" amino acids 23 to 1044 (1022 residues), 530.8 bits, see alignment E=3.2e-163

Best Hits

KEGG orthology group: None (inferred from 76% identity to pna:Pnap_2959)

Predicted SEED Role

"Probable transmembrane drug efflux protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1053 amino acids)

>GFF4033 Probable transmembrane drug efflux protein (Hydrogenophaga sp. GW460-11-11-14-LB1)
MNDASSTTPAGDTGSWVSRFNLSQWALDHQAFTRYLMIVLMVLGVVGYFQLGQDEDPPFT
FRAMVVRAYWPGATAEQVAEQVADRIEKTLQEVPYADKIRSYSKPGETLIIFQLKDSSPP
QEVQQIWYTARKKVGDMRGTLPQGVVGPFFNDEFGDVYGVIYALQGEGFSPADKKQVADD
VRQRLLRVKDVRKVELFGVQDEKLYIEISQKRLATLGLNLQQVLDALGQQNAVESAGSVQ
TPQDVVQVRVAGAFNSVEQLRAMPIRAANGTQIRLGDIAKIGLGYVDPPQVLVRHEGKDS
IALGISMAKGGDIIALGKALKTTVAGIEATLPAGMTLAQVQDQPSAVTNSVNEFVKVLIE
AVVIVLAVSFLALGLHRRPGGRGLKRYVLDMRPGLVVFITIPLVLAITFLAMHYWGIGLH
KISLGSLIIALGLLVDDAIIAVEMMVRKLEEGYDMMRAATFTWDATAMPMLTGTLITAAG
FLPIGLANSTTGEYTFAIFAVTVLALVISWVVAVLFVPYLGVVLLKVKPHAEGEPHEVFD
GPFYVRFRAVVDWCVQHRWLTIGATILTFVLGIAGMGSVQQQFFPDSSRPEILVDIWLPE
GSSMPAMDEVTRRVENRLAKEEGVRGVTTWVGSGVPRFYLPLDQIFPQTNVSQMIVLPQD
LKTREHLRKALPGLLATEFPEVRGRVKLLPNGPPVPYPVQFRVVGSDPQVLRGLADEVKL
AMRENPNMRGVNDNWNESVKRLRLEVDQAKARALGVSSQSIAQASRTLLSGTTVGQYREG
DKLIDIVLRQPLEERDAITSLANAYLPTASGQAIPLLQIARPVFDWEPGVLWRENRDYAI
TVQGDVVEGLQGATVTAQLQPKLKAISDGWASKGLGAYHIEVAGAVEESSKGSASIVVGV
PLMLFIVFTLLMLQLQSFSRSMLVFLTGPLGMAGVAGALLLLNRPFGFVALLGVIALMGM
IQRNSVILIDQIEQDRARGVPAWDAIVEAAVRRMRPIVLTAAAAVLAMIPLSRSVFWGPM
AVAIMGGLIVATVLTLLALPAMYAAWFRVRRPA