Protein Info for GFF4009 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: DNA polymerase III alpha subunit (EC 2.7.7.7)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1035 TIGR00594: DNA polymerase III, alpha subunit" amino acids 9 to 845 (837 residues), 525.5 bits, see alignment E=1.5e-161 PF02811: PHP" amino acids 12 to 106 (95 residues), 56.8 bits, see alignment E=8.8e-19 PF07733: DNA_pol3_alpha" amino acids 281 to 535 (255 residues), 299.3 bits, see alignment E=7.3e-93 PF17657: DNA_pol3_finger" amino acids 538 to 707 (170 residues), 179 bits, see alignment E=1.2e-56 PF14579: HHH_6" amino acids 781 to 866 (86 residues), 71.9 bits, see alignment E=1e-23 PF01336: tRNA_anti-codon" amino acids 948 to 1019 (72 residues), 28.9 bits, see alignment 2.2e-10

Best Hits

Swiss-Prot: 55% identical to DNAE2_PSEAE: Error-prone DNA polymerase (dnaE2) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K14162, error-prone DNA polymerase [EC: 2.7.7.7] (inferred from 67% identity to aav:Aave_2732)

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1035 amino acids)

>GFF4009 DNA polymerase III alpha subunit (EC 2.7.7.7) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MSADVLPDYVELRCLSNFSFLRGASHPEELVERAAALGYQALALVDECSLAGVVRAHVAA
KKHRFQLLIGSQFQVRCDAPFTLVVLACNLNGYGNLCEFITRLRRSAPKGSYRLAIGDID
AQALADCVVIAVPDRHSDQDPMDTVARWLLQHFRGRCWLGVEQLCRFDDEMRLHRLRQSS
ELTAVPLVAVGDVRMHVRSRKPLHDVLTATRIGKPLTECGFVLEPSAEQRLRGRLTLGQL
YPADLLAETLAVAARCDFSLDELRYQYPSEVIPEGETPQSHLRQLTEAGARRRWPQGTPE
AFAQQIEHELELIAYKQYEHYFLTVHDIVAFARSKDILCQGRGSAANSVVCYCLGITEVD
PGRTGLLFERFISRERDEPPDIDVDFEHERREEVIQYLYGKYGRERAALTATVISYRPRS
ALRDVGKALGFAEGSLDVLARQSRWWDGHAIAPERLQEAGLDTGDLKVRQLLELTSTLMG
FPRHLSQHTGGFVLTQLPLSRLVPIENATMKDRTVIEWDKDDLDAVGLLKVDVLALGMLT
ALRKAMALIGEKQGRAFGMQDIPDGDDPTYDMVCAADTVGVFQIESRAQMSMLPRLRPRS
YYDLVIEVALVRPGPIQGGAVHPYLNRRQGKVPVSFPGPHGGRALKAALGRTMGVPIFQE
QCMQIAVLSAGFTPGEADELRRAMAAWKRHGNVQKYEERLVKGMTDRGYELEFAQSIFEQ
IKGFSSYGFPESHAASFALLVYVSAWIKCHHPAEFLTALLNSQPLGFYTPSQLVQDAKRH
GVVVRPVDVLHSDRDSTIDADGAVRLGMRLVSGIGQDATERIVQARAQQAFRNAQDLARR
AGLDQPQMKALAAADALMGLSGHRRQQVWDAAALRSPPALLKGAPVDEAPLALPAAPEGE
AVVWDYASTGLTLRRHPLALLREELAKRRLMTAAQLQDAPDGRLVRHCGIVTLRQQPGTS
SGVVFVSLEDETGVVQVIVWQRIRERQRAVLTGARLLAVYGRWQREGEVRNLIAGHLEDL
TPLLNGLSTVSRDFH