Protein Info for GFF4002 in Xanthobacter sp. DMC5

Annotation: Homospermidine synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 476 PF03435: Sacchrp_dh_NADP" amino acids 14 to 156 (143 residues), 117.7 bits, see alignment E=4.4e-38 PF16653: Sacchrp_dh_C" amino acids 160 to 440 (281 residues), 116.5 bits, see alignment E=2.5e-37

Best Hits

Swiss-Prot: 75% identical to HSS_BLAVI: Homospermidine synthase (hss) from Blastochloris viridis

KEGG orthology group: K00808, homospermidine synthase [EC: 2.5.1.44] (inferred from 93% identity to xau:Xaut_2138)

MetaCyc: 75% identical to homospermidine synthase monomer (Blastochloris viridis)
Homospermidine synthase. [EC: 2.5.1.44, 2.5.1.45]; 2.5.1.44 [EC: 2.5.1.44, 2.5.1.45]; 2.5.1.44 [EC: 2.5.1.44, 2.5.1.45]

Predicted SEED Role

"Homospermidine synthase (EC 2.5.1.44)" (EC 2.5.1.44)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.5.1.44 or 2.5.1.45

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (476 amino acids)

>GFF4002 Homospermidine synthase (Xanthobacter sp. DMC5)
MSDWPVHAKIDGPIVMIGFGSIGRGTLPLIERHFDFDRERMVVIDPVADHRKLLDSRGIR
YVQSEVTAENYRDLLTPLLTNGGGRGFCVNLSVDVSSVAVMELCREIGALYIDTVVEPWK
GFYFDEAMPTAARTNYALRESLLAARRRNPGGTTAVSTCGANPGMVSWFVKQAMLNIAAD
TGLDRPEPKTREEWAQFARSLGIKGIHIAERDTQRAREPKVMGQFWNTWSVEGFVSEGLQ
PAELGWGTHEKTLPADGRTHEGGCGAAIYLLSAGAATRVRSWTPTPQAQYGFLVTHNESI
SIADYLTVRDGDQVLYRPTCHYAYHPCNDAVLSLHEMFGNGGHFQESWKILDEHEIVDGI
DELGVLIYGHARNAYWFGSQLSIEETRELAPYQNATGLQVTSAVLAGMVWALENPEAGIV
EADEMDFRRCLEVQLPYLGPVIGTYTDWTPLTGRQKLFPEDLDLEDPWQFKNIIVR