Protein Info for GFF3998 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Cobyric acid synthase (EC 6.3.5.10)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 483 PF01656: CbiA" amino acids 6 to 225 (220 residues), 67.7 bits, see alignment E=1.4e-22 PF13500: AAA_26" amino acids 6 to 226 (221 residues), 43.7 bits, see alignment E=4.4e-15 TIGR00313: cobyric acid synthase CobQ" amino acids 6 to 443 (438 residues), 413.9 bits, see alignment E=4.7e-128 PF07685: GATase_3" amino acids 252 to 443 (192 residues), 156.4 bits, see alignment E=1.1e-49

Best Hits

Swiss-Prot: 80% identical to COBQ_VARPS: Cobyric acid synthase (cobQ) from Variovorax paradoxus (strain S110)

KEGG orthology group: K02232, adenosylcobyric acid synthase [EC: 6.3.5.10] (inferred from 80% identity to vap:Vapar_2565)

Predicted SEED Role

"Cobyric acid synthase (EC 6.3.5.10)" (EC 6.3.5.10)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.5.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (483 amino acids)

>GFF3998 Cobyric acid synthase (EC 6.3.5.10) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MTARCVMVLGTTSGAGKSWLTTALCRHYARQGLKVAPFKAQNMSNNARVVEGGEIGSAQY
FQSLAARAEPEVRMNPLLLKPEADTRSQVVLMGQVNETLSNLPWRGRSLQVWPQIAAALD
ALRAENDVVVIEGAGSPAEINLHASDIVNMRVALHAQARCLLVTDIDRGGAFAHLYGTWA
LLPPEERALIHGFVLNKFRGDASLLAPAPQQLHELTGVPTVAVLPMWWQHGLPEEDGVFD
DRTRASGAVSRTVAVIAYPRISNLDEFQPLKNVPGVRLVWARAPADCAGADWIVLPGSKA
TASDLAWLRSQGLDRAIAAHAAQGGAVLGVCGGLQMLGEALIDTHGIDGNAPGLGLLPLV
TQFEPQKTVRHTRTRFGRLTGAWAALSGVDAAGYEIHHGQTLPHAAMAAAGDVAREALPD
GLGWQNAQGNVLGVYLHGLFEDPRVLHALFGATVPTLETVFDGLADFLQTHVESGVLDQL
IGN