Protein Info for GFF3987 in Xanthobacter sp. DMC5

Annotation: Lipoprotein signal peptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 176 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details transmembrane" amino acids 67 to 86 (20 residues), see Phobius details amino acids 94 to 116 (23 residues), see Phobius details amino acids 130 to 149 (20 residues), see Phobius details TIGR00077: signal peptidase II" amino acids 5 to 154 (150 residues), 103.2 bits, see alignment E=7.1e-34 PF01252: Peptidase_A8" amino acids 12 to 152 (141 residues), 116.3 bits, see alignment E=6.7e-38

Best Hits

Swiss-Prot: 37% identical to LSPA_POLNS: Lipoprotein signal peptidase (lspA) from Polynucleobacter necessarius subsp. necessarius (strain STIR1)

KEGG orthology group: K03101, signal peptidase II [EC: 3.4.23.36] (inferred from 80% identity to xau:Xaut_2206)

Predicted SEED Role

"Lipoprotein signal peptidase (EC 3.4.23.36)" in subsystem Sex pheromones in Enterococcus faecalis and other Firmicutes or Signal peptidase (EC 3.4.23.36)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.23.36

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (176 amino acids)

>GFF3987 Lipoprotein signal peptidase (Xanthobacter sp. DMC5)
LQRRPIVFGLLVALAVLVADQASKGIVLAWSASWDAQIKPVAPFIDFAALWNYGISYGLF
PQGETGRWVLVAIKVAAAILFAVWLARARSRFEAFALGLLIGGAIGNAVDRVVYGAVFDF
VSLHAFGYRWYVFNLADVAVVVGVGLLLYDAFLGGASKSPPSAAPMAPRSEAEREP