Protein Info for GFF3987 in Variovorax sp. SCN45

Annotation: 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00106: adh_short
  • amino acids 10 to 197 (188 residues), 204.9 bits, E=1.4e-64
• PF08659: KR
  • amino acids 12 to 162 (151 residues), 59.4 bits, E=6.7e-20
• PF13561: adh_short_C2
  • amino acids 15 to 255 (241 residues), 196.5 bits, E=8.1e-62

Best Hits

KEGG orthology group: None (inferred from 90% identity to vpe:Varpa_1665)

MetaCyc: 38% identical to BadH (Rhodopseudomonas palustris)
R267-RXN

Predicted SEED Role

"D-beta-hydroxybutyrate dehydrogenase (EC 1.1.1.30)" in subsystem Polyhydroxybutyrate metabolism (EC 1.1.1.30)

MetaCyc Pathways

• ketogenesis (5/5 steps found)
• ketolysis (3/3 steps found)
• benzoyl-CoA degradation III (anaerobic) (4/9 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Synthesis and degradation of ketone bodies

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.30

Use Curated BLAST to search for 1.1.1.30

Protein Sequence (258 amino acids)

>GFF3987 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) (Variovorax sp. SCN45)
MYSNSLTGRHALVTGAARGIGAEIARTLAAQGALLTLLGRDREALQRVADSLEGDGHGVV
AADVANQEAVQAAFAEARAVRGPVAILVNNAGAAESAPFLKTSFDLWQRMLSVNLTGSFL
CAQAALPDMLDAGWGRIVNIASTAGQKGYAYVAAYTAAKHGVVGLTRSLALEVARKGITV
NAVCPGYTDTDILRNSVANVVGKTGRSEADALAEFSSVNPQRRIVQPAEVADTVRWLCGE
GAASVTGQSISVSGGEVT