Protein Info for GFF3967 in Variovorax sp. SCN45

Annotation: Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 730 PF02775: TPP_enzyme_C" amino acids 453 to 595 (143 residues), 64.1 bits, see alignment E=6.8e-22

Best Hits

KEGG orthology group: K00179, indolepyruvate ferredoxin oxidoreductase, alpha subunit [EC: 1.2.7.8] (inferred from 97% identity to vap:Vapar_1490)

Predicted SEED Role

"Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8)" in subsystem Aromatic amino acid interconversions with aryl acids (EC 1.2.7.8)

Isozymes

Compare fitness of predicted isozymes for: 1.2.7.8

Use Curated BLAST to search for 1.2.7.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (730 amino acids)

>GFF3967 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) (Variovorax sp. SCN45)
MAERSFVEEVKKLRLSGGEVFRGEGILAVTKALLESGVSYVAGYQGAPISHLMDVLADAQ
DILADHGIRFENSASEATAAATLAASVNYPLRGAVTFKATVGTNVASDALANLASGGVTG
GALIIVGEDYGEGSSIMQERSHAFAMKSQIWLLDPRPNLPSIVDAVKQGFDLSEASSTPV
MLQLRIRACHVHGHFVAGDNKRAKFTLKDALENPRRDVGRIVLPPASFVHEQEKVKDRWP
AAVRFIEERKLNEFFSEDADDIGIIVQGGSYNTLLRALERLGLADVYGNTQVPLYVMNVA
YPVIESEVIRFCKGKRAVMIVEEGQPNFVEQNLATILRQAGSNTALHGKDMLPVAGEYTA
AELLKGARSFCERYGRLAPLPVPAPVRKVIPLKEVAAIGVDAAPEPVQPSTALGDVVHAR
PPGFCTGCPERPIFSAMKLVERELGPHHVSADIGCHLFSILPPFNIGNTTMGYGLGGAGA
AALNAPAGKRAISMMGDGGFWHNGLTSGVANAVFNKSDNLTIVVDNNYTSATGGQDILSS
HAVNKTRSTGHEIERAVRGVGVEWVKTMRRTYDIAGMRDALKEALTTKEKGPKVLIAQSE
CMLNKQRREKPLVRKAIADGKRMVREKFGVDSDTCTGDHSCIRLSGCPSLSIKPNPDPLR
TDPVATVLDSCVGCGVCGEVSHAAVLCPSFYKAQIVSNPSRWDMLRERVRAAVIGWLQRG
EARRREAYAF