Protein Info for GFF3966 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Cobyric acid synthase (EC 6.3.5.10)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 506 PF13500: AAA_26" amino acids 4 to 228 (225 residues), 74 bits, see alignment E=2.3e-24 TIGR00313: cobyric acid synthase CobQ" amino acids 5 to 494 (490 residues), 539.7 bits, see alignment E=3.3e-166 PF01656: CbiA" amino acids 5 to 228 (224 residues), 82.6 bits, see alignment E=3.7e-27 PF07685: GATase_3" amino acids 253 to 447 (195 residues), 204.3 bits, see alignment E=2.4e-64

Best Hits

Swiss-Prot: 100% identical to CBIP_SALTY: Cobyric acid synthase (cbiP) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K02232, adenosylcobyric acid synthase [EC: 6.3.5.10] (inferred from 100% identity to stm:STM2019)

MetaCyc: 100% identical to adenosyl-cobyrate synthase subunit (Salmonella enterica enterica serovar Typhimurium)
Adenosylcobyric acid synthase (glutamine-hydrolyzing). [EC: 6.3.5.10]

Predicted SEED Role

"Cobyric acid synthase (EC 6.3.5.10)" (EC 6.3.5.10)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.5.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (506 amino acids)

>GFF3966 Cobyric acid synthase (EC 6.3.5.10) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MTQAVMLQGTASDVGKSVLAAGLCRIFYQDGLRTAPFKSQNMALNSGITPDGKEMGRAQI
FQAEAAGITPDVRMNPVLLKPTSDRQAQVVLMGKVATNMDAVSYHDYKPRLREQILAVYN
SLAQEYDVIVLEGAGSPAEINLRDRDIVNMGMAEMAQCPVILVADIDRGGVFAAIYGTLA
LLHKQERDRVKGVIINKFRGDVALLYSGIEQIESLTGVPVLGVMPWLDVDLEDEDGVALQ
NDKYRGNAPRDITIAIVQLPHISNFTDFNALAAQPDVRIRYIRRPEALTDVDLVILPGSK
NTLSDLAWLRESGMADAVLQTHRQGVPVMGICGGYQMLGDTIVDEVESGLGTQPGLGLLN
TITRFAQDKTTTQVNATMSGELPGWLAAAAGLPVRGYEIHMGETVLQEGCCTAMTLQKNG
CSVADGAVTADGLAFGTYLHGLFDSDAFTRAVVNGLRARKGLAPWETTFCYADHKARQFD
LLAEAMRQHIDIDKIYTIMQQHQEPV