Protein Info for GFF3948 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Thymidine phosphorylase (EC 2.4.2.4)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 834 PF07793: DUF1631" amino acids 1 to 194 (194 residues), 75.3 bits, see alignment E=7.6e-25 PF26671: DUF1631_2nd" amino acids 375 to 477 (103 residues), 59.6 bits, see alignment E=5.4e-20 PF26672: DUF1631_3rd" amino acids 515 to 624 (110 residues), 48.3 bits, see alignment E=1.5e-16

Best Hits

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (834 amino acids)

>GFF3948 Thymidine phosphorylase (EC 2.4.2.4) (Hydrogenophaga sp. GW460-11-11-14-LB1)
LLQQCFQEALSGAPDMLARCADAAIASLQAAEKASREVAQRDRLALAWWGLLQNKIQWGR
NFSQHLRDALMASPEANSSRPALLSESSLLSLVEDDAVNESLESARLVHSLMPVLEPQLG
VLDALMSSVIGLQTVQAERNPMRPSVFVRALRELMASAESEPEVRALWLRHMGDALGREL
QKLYERVALILQRANVQEAGYRVRLVEESGASTRSGGLSTRSGGLGLSSRAAGLGVPSNS
HWQDAGDTGGSGHHAPGWSSTDQLPPMQTLARMQPAEDHQVFHDFLKQGGKHFERHLTPD
YYEQVSEELAAIEAFAAIPVLDESMILEQQTQYRDLPVVDRPAREIGISSQLSHKAWGTY
AAAHERSRVLMHLKQKAQRVSQAVGLDLVRTLVSQVASDPLLLGPVREAVVALEPALLRL
AMANPRFFNEDEHPARRLIESVAQRSFKFNDEFTEEFDSFFQPVQSAFNELNATATRDPQ
PFADVLAELRQGWEVQDQKELALQDNSLQSIRYAEERQAMADQIAWDLSQRPDVDNAPGV
ILDFLYGPWALVIASATLREPDQSDPGGYRKMVSNLLWSVKKEVTLKRPKELFAMVPGML
ATLHAGLDMLGKTREETKPFFDALMRLHQPVLGLRRARIRADASHSGLPQMEHSGSMPLE
DVPSSMSMELDETLPATAEQRKPRPRAQPWLGKRELEAAGFEDTMPTDYGDLIETQVQAR
ASEDDSQAAALVEEAEELEDINAAATLMGLHEGDWVDLYSHREWLRAQLIWASSKGTLFM
FVSRGGRPHSMTKRSCERLIASRLLRPVNAQQGVVKKALDAMAAEPARRAPVPA