Protein Info for GFF3942 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: ClpB protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 872 TIGR03346: ATP-dependent chaperone protein ClpB" amino acids 6 to 855 (850 residues), 1372.4 bits, see alignment E=0 PF02861: Clp_N" amino acids 17 to 67 (51 residues), 41.1 bits, see alignment 9.7e-14 amino acids 93 to 143 (51 residues), 37.8 bits, see alignment 1e-12 PF00004: AAA" amino acids 201 to 333 (133 residues), 47.3 bits, see alignment E=1.7e-15 amino acids 609 to 731 (123 residues), 38.4 bits, see alignment E=9.9e-13 PF17871: AAA_lid_9" amino acids 340 to 438 (99 residues), 118.5 bits, see alignment E=7.2e-38 PF07724: AAA_2" amino acids 603 to 765 (163 residues), 236.8 bits, see alignment E=8.4e-74 PF00158: Sigma54_activat" amino acids 607 to 726 (120 residues), 21.4 bits, see alignment E=1.1e-07 PF07728: AAA_5" amino acids 608 to 728 (121 residues), 47.5 bits, see alignment E=1.2e-15 PF10431: ClpB_D2-small" amino acids 772 to 850 (79 residues), 83.9 bits, see alignment E=3.8e-27

Best Hits

Swiss-Prot: 78% identical to CLPB_RALSO: Chaperone protein ClpB (clpB) from Ralstonia solanacearum (strain GMI1000)

KEGG orthology group: K03695, ATP-dependent Clp protease ATP-binding subunit ClpB (inferred from 85% identity to aav:Aave_1249)

Predicted SEED Role

"ClpB protein" in subsystem Protein chaperones or Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (872 amino acids)

>GFF3942 ClpB protein (Hydrogenophaga sp. GW460-11-11-14-LB1)
MRLDKLTTKFQEALGEAQTLALGADNAYIEPAHLLLALLRQADGPQSLLQRAGVNVPGLA
KAAEAAVKRLPEVQGQEQVQVGPELAKLLQATEKEALKRGDQFIASELFLLAVTDHKGEL
GRIANENGLNRKSLEAAITAVRGGQKMDSPEAEGQREALKKYTLDLTERARLGKLDPVIG
RDDEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGEVPDSLKGKRVLSLDM
AALLAGAKFRGEFEERLKTVLNELAKDEGQTIVFIDELHTMVGAGKAEGAMDAGNMLKPA
LARGELHCVGATTLDEYRKYIEKDAALERRFQKILVGEPSVEATIAILRGLQEKYEVHHG
VQITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAASKIKIELDSKPEVMDRLDRRLIQL
QIEREAVRREKDEASQKRFGLIEEEIVRLEKEISDYDEIWKAEKAAALGSKDVMEEMDRI
RSQIKTFTDKGDFNKVAELQYGKLPELEKRLKDAQAVESGKALNKDGKGRPQLLRTQVGA
EEIAEVVARATGIPVSKLMQGERDKLLLMEGKLHERVVGQDEAIGAVANAIRRSRSGLSD
PNRPTGSFLFLGPTGVGKTELCKALAGFLFDSEDHLIRIDMSEFMEKHSVARLIGAPPGY
VGYEEGGYLTEAVRRKPYSVVLLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTV
IVMTSNIGSHMIQAMVGSPYDEVKEAVWDELKNHFRPEFLNRIDETVVFHALDAQHIESI
AAIQLKVLEARLAKMDLHLNVSSAALAELAKVGFDPVFGARPLKRAIQQRIENPLSKYLL
EGRYPPKSSIPVDVDPVQNPGVFEFGDAVVPA