Protein Info for GFF394 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: L-threonine 3-dehydrogenase (EC 1.1.1.103)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00692: L-threonine 3-dehydrogenase
  • amino acids 3 to 340 (338 residues), 625.1 bits, E=1.4e-192
• PF08240: ADH_N
  • amino acids 26 to 134 (109 residues), 114.4 bits, E=3.4e-37
• PF00107: ADH_zinc_N
  • amino acids 174 to 303 (130 residues), 100.9 bits, E=7.9e-33

Best Hits

Swiss-Prot: 100% identical to TDH_SALSV: L-threonine 3-dehydrogenase (tdh) from Salmonella schwarzengrund (strain CVM19633)

KEGG orthology group: K00060, threonine 3-dehydrogenase [EC: 1.1.1.103] (inferred from 100% identity to spq:SPAB_04605)

MetaCyc: 97% identical to threonine dehydrogenase (Escherichia coli K-12 substr. MG1655)
L-threonine 3-dehydrogenase. [EC: 1.1.1.103]

Predicted SEED Role

"L-threonine 3-dehydrogenase (EC 1.1.1.103)" in subsystem Glycine Biosynthesis or Threonine degradation (EC 1.1.1.103)

MetaCyc Pathways

• superpathway of L-threonine metabolism (17/18 steps found)
• L-threonine degradation II (2/2 steps found)
• aminopropanol phosphate biosynthesis II (3/4 steps found)
• L-threonine degradation III (to methylglyoxal) (2/3 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.103

Protein Sequence (341 amino acids)

>GFF394 L-threonine 3-dehydrogenase (EC 1.1.1.103) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MKALSKLKAEEGIWMTDVPEPEVGHNDLLIKIRKTAICGTDVHIYNWDDWSQKTIPVPMV
VGHEYVGEVVGIGQEVKGFKIGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRPGC
FAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGVMAA
AVAKHVGARHVVITDVNEYRLELARKMGVTRAVNVAKESLNDVMAELGMTEGFDVGLEMS
GAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAA
LIQSGLDLSPIITHRFSIDDFQKGFDAMRSGQSGKVILSWD