Protein Info for GFF3934 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868
Annotation: CoA-acylating propionaldehyde dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K13922, propionaldehyde dehydrogenase (inferred from 100% identity to see:SNSL254_A2228)MetaCyc: 100% identical to CoA-dependent propanal dehydrogenase (Salmonella enterica enterica serovar Typhimurium str. LT2)
RXN-12736 [EC: 1.2.1.87]; 1.2.1.87 [EC: 1.2.1.87]; 1.2.1.87 [EC: 1.2.1.87]
Predicted SEED Role
"CoA-acylating propionaldehyde dehydrogenase" in subsystem Propanediol utilization
MetaCyc Pathways
- (S)-propane-1,2-diol degradation (5/5 steps found)
- 1,2-propanediol biosynthesis from lactate (engineered) (2/6 steps found)
- androstenedione degradation I (aerobic) (7/25 steps found)
- superpathway of testosterone and androsterone degradation (7/28 steps found)
- superpathway of cholesterol degradation I (cholesterol oxidase) (9/42 steps found)
- superpathway of cholesterol degradation II (cholesterol dehydrogenase) (9/47 steps found)
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.2.1.87
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (464 amino acids)
>GFF3934 CoA-acylating propionaldehyde dehydrogenase (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868) MNTSELETLIRTILSEQLTTPAQTPVQPQGKGIFQSVSEAIDAAHQAFLRYQQCPLKTRS AIISAMRQELTPLLAPLAEESANETGMGNKEDKFLKNKAALDNTPGVEDLTTTALTGDGG MVLFEYSPFGVIGSVAPSTNPTETIINNSISMLAAGNSIYFSPHPGAKKVSLKLISLIEE IAFRCCGIRNLVVTVAEPTFEATQQMMAHPRIAVLAITGGPGIVAMGMKSGKKVIGAGAG NPPCIVDETADLVKAAEDIINGASFDYNLPCIAEKSLIVVESVAERLVQQMQTFGALLLS PADTDKLRAVCLPEGQANKKLVGKSPSAMLEAAGIAVPAKAPRLLIALVNADDPWVTSEQ LMPMLPVVKVSDFDSALALALKVEEGLHHTAIMHSQNVSRLNLAARTLQTSIFVKNGPSY AGIGVGGEGFTTFTIATPTGEGTTSARTFARSRRCVLTNGFSIR