Protein Info for GFF3932 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868
Annotation: Cob(III)alamin reductase @ Cob(II)alamin reductase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: None (inferred from 100% identity to seh:SeHA_C2276)MetaCyc: 100% identical to cob(II)alamin reductase (Salmonella enterica enterica serovar Typhimurium str. LT2)
Cob(I)yrinic acid a,c-diamide adenosyltransferase. [EC: 2.5.1.154, 2.5.1.17]
Predicted SEED Role
"Cob(III)alamin reductase @ Cob(II)alamin reductase"
MetaCyc Pathways
- adenosylcobalamin biosynthesis II (aerobic) (29/33 steps found)
- adenosylcobalamin biosynthesis I (anaerobic) (31/36 steps found)
- superpathway of adenosylcobalamin salvage from cobinamide I (8/8 steps found)
- adenosylcobinamide-GDP biosynthesis from cobyrinate a,c-diamide (6/6 steps found)
- superpathway of adenosylcobalamin salvage from cobinamide II (8/9 steps found)
- adenosylcobalamin salvage from cobalamin (5/5 steps found)
- adenosylcobinamide-GDP salvage from cobinamide I (5/5 steps found)
- adenosylcobinamide-GDP salvage from cobinamide II (5/6 steps found)
- cobalamin salvage (eukaryotic) (4/8 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.5.1.17
Use Curated BLAST to search for 2.5.1.154 or 2.5.1.17
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (451 amino acids)
>GFF3932 Cob(III)alamin reductase @ Cob(II)alamin reductase (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868) MSTAINSVEMSLSADEIRERVRAAGVVGAGGAGFPAHVKLQAQVEIFLVNAAECEPMLKV DQQLMWQQAARLVRGVQYAMTATGAREGVIALKEKYRRAIDALTPLLPDGIRLHILPDVY PAGDEVLTIWMATGRRVAPAALPASVGVVVNNVQTVLNIARAVEQRFPVTRRTLTVNGAV ARPLTVTVPIGMSLREVLALAGGATVDDPGFINGGPMMGGLITSLDNPVTKTTGGLLVLP KSHPLIQRRMQDERTVLSVARTVCEQCRLCTDLCPRHLIGHELSPHLLVRAVNFHQAATP QLLLSALTCSECNVCESVACPVGISPMRINRMLKRELRAQNQRYEGPLNPADEMAKYRLV PVKRLIAKLGLSPWYQEAPLVEEEPSVEKVTLQLRQHIGASAVANVAVGERVTRGQCVAD VPPGALGAPIHASIDGVVSAISEQAITVVRG