Protein Info for GFF3908 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: probable oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00258: Flavodoxin_1
  • amino acids 53 to 179 (127 residues), 96.4 bits, E=1.8e-31
• PF00175: NAD_binding_1
  • amino acids 326 to 431 (106 residues), 44.8 bits, E=1.8e-15

Best Hits

KEGG orthology group: K00380, sulfite reductase (NADPH) flavoprotein alpha-component [EC: 1.8.1.2] (inferred from 58% identity to mpt:Mpe_A3726)

Predicted SEED Role

"probable oxidoreductase"

MetaCyc Pathways

• superpathway of L-methionine biosynthesis (by sulfhydrylation) (11/12 steps found)
• superpathway of sulfate assimilation and cysteine biosynthesis (8/9 steps found)
• assimilatory sulfate reduction III (3/3 steps found)
• assimilatory sulfate reduction I (3/4 steps found)
• superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (7/10 steps found)

KEGG Metabolic Maps

• Sulfur metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.2

Use Curated BLAST to search for 1.8.1.2

Protein Sequence (459 amino acids)

>GFF3908 probable oxidoreductase (Hydrogenophaga sp. GW460-11-11-14-LB1)
MTSEKMLYALATLLCYALLCVAMAWQHRNRQRAAQRRVDALLPATPGVPAWWVAYASQTG
QAEELALQTAQALHTAGVPVRLAPLSQISLADLQQADRLLCIASTYGEGDPPDSAVPFAR
QVMADAGVTLSHLHVGLLALGDKTYAHFCGFGRQLDQWLTDRGAQALFERIDVDKSDPDA
LQRWRQHLAHLAGTSDLPDWEAPALQPWRLRTREHLNPGSAGEEVHHLELVPEAAGAALP
EWQAGDLVQVEVPAAPGEPRDYSIASVPQDGAVHLLVRRTRRADGSPGQASGWLTQAAQT
GETVMLRVRPHGGFRIGDNAQRPLILIGNGTGLAGLRGHMRARVAAGKGQAPMWLLFGER
NATCDAHYRDEIDAWQRDGWLRRVDWVFSRDQVERLYVQHALAEAADTVRQWVADGAAIY
VCGSLEGMAGEVNATLQTILGEEALQQLAADGRYRRDVY