Protein Info for GFF3901 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Macrolide-specific efflux protein MacA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 641 transmembrane" amino acids 26 to 46 (21 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 59 to 338 (280 residues), 156.2 bits, see alignment E=5.2e-50 PF16576: HlyD_D23" amino acids 67 to 315 (249 residues), 68.3 bits, see alignment E=1.2e-22 PF13533: Biotin_lipoyl_2" amino acids 85 to 129 (45 residues), 36.1 bits, see alignment 9.1e-13 PF13437: HlyD_3" amino acids 206 to 304 (99 residues), 45 bits, see alignment E=3.1e-15

Best Hits

Predicted SEED Role

"Macrolide-specific efflux protein MacA" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (641 amino acids)

>GFF3901 Macrolide-specific efflux protein MacA (Hydrogenophaga sp. GW460-11-11-14-LB1)
LLSFMNEVQREGGKAPAVRRRKTWKLALIALVSLAVLGGGGFAYYRWGPGAKTESAYITA
TVQRGDIEDQVSATGSLQPRDYVDVGAQVSGQLRKIHVEVGTEVKEGDLLAEIDAETSMA
RVDASRAQLRSQQAQMGERELTLAKAERDLQRQKNLMAEEATTAETLQNAETAVKTARAQ
ILSLKASMEQLQASMRVEEANLKYTKIYAPMAGTVVSITARQGQTLNTNQSAPTLMRIAD
LSVMTVQTQVSEADVSKLRGGMPVYFTTLGGQGRRWYGELKKIEPTPTVTNNVVLYNALF
EVPNNNRSLMTQMTAQVFFVVAEAKDVLVVPMSALTIQRGAQGNRGGQQGGPGGARNNPG
AGVPAPAAPSGTTPAPATPGAAPAAPTQRGTSTSAIPSASFKTVADTVVVAQAGGERPRM
DREAFEKMTEEERARFREQRRKEREAAGGAAPGAAGGGNGPGAGGERPRMDREAFEKMSE
EERARFREQRRKEREQAQASGGNAATAPAAGGAAAAQKRPAPGAEAGSKDAAATKPAAPN
VSGMPARGDGPARPARGPRQAKVKVMAEDGTIEEREVTIGISNRVHAEVLSGLKEGDRVI
AGVREPERRPANTQQGTGLGQQPNMGGPGGMPAGAAGGARR