Protein Info for GFF3873 in Variovorax sp. SCN45

Annotation: Pyridoxine 5'-phosphate synthase (EC 2.6.99.2)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03740: PdxJ
  • amino acids 10 to 248 (239 residues), 271.4 bits, E=2.5e-85
• TIGR00559: pyridoxine 5'-phosphate synthase
  • amino acids 10 to 248 (239 residues), 206.1 bits, E=3e-65

Best Hits

Swiss-Prot: 68% identical to PDXJ_RHOFT: Pyridoxine 5'-phosphate synthase (pdxJ) from Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118)

KEGG orthology group: K03474, pyridoxine 5-phosphate synthase [EC: 2.6.99.2] (inferred from 88% identity to vpe:Varpa_1546)

Predicted SEED Role

"Pyridoxine 5'-phosphate synthase (EC 2.6.99.2)" in subsystem Pyridoxin (Vitamin B6) Biosynthesis (EC 2.6.99.2)

MetaCyc Pathways

• pyridoxal 5'-phosphate biosynthesis I (6/7 steps found)
• superpathway of pyridoxal 5'-phosphate biosynthesis and salvage (7/12 steps found)

KEGG Metabolic Maps

• Vitamin B6 metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.99.2

Protein Sequence (253 amino acids)

>GFF3873 Pyridoxine 5'-phosphate synthase (EC 2.6.99.2) (Variovorax sp. SCN45)
MSTSGNVTSLSVNLNKVALVRNTRHLGIPSVVKAAQACLAAGAQGITVHPRPDARHIRAH
DVSDLSELLAKDWPAIEFNIEGNPFQNLMDFVRALKPHQATFVPDSETQSTSDHGWTFPD
DAERLRPLIAEAKALGVRVSLFMDPIPEMMAAVKAVGADRVELYTEGYAASRGTPDEQAV
LQRYADTARAAHAAGLGINAGHDLSRDNLTAFLRAVPNVLEVSIGHAFVADALELGYAAA
TRDYLRCISEAQQ