Protein Info for GFF387 in Variovorax sp. SCN45

Annotation: 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00243: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • amino acids 6 to 389 (384 residues), 472 bits, E=7.1e-146
• PF02670: DXP_reductoisom
  • amino acids 8 to 136 (129 residues), 147.4 bits, E=5.8e-47
• PF08436: DXP_redisom_C
  • amino acids 150 to 236 (87 residues), 126.9 bits, E=4.1e-41
• PF13288: DXPR_C
  • amino acids 268 to 384 (117 residues), 122.2 bits, E=2.1e-39

Best Hits

Swiss-Prot: 60% identical to DXR_CUPTR: 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr) from Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1)

KEGG orthology group: K00099, 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC: 1.1.1.267] (inferred from 95% identity to vap:Vapar_2605)

Predicted SEED Role

"1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267)" in subsystem Isoprenoid Biosynthesis or polyprenyl synthesis (EC 1.1.1.267)

MetaCyc Pathways

• methylerythritol phosphate pathway II (8/9 steps found)
• superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) (10/12 steps found)
• taxadiene biosynthesis (engineered) (10/13 steps found)
• methylerythritol phosphate pathway I (7/9 steps found)
• isoprene biosynthesis I (7/10 steps found)
• superpathway of ergosterol biosynthesis II (11/26 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Terpenoid biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.267

Protein Sequence (395 amino acids)

>GFF387 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) (Variovorax sp. SCN45)
VNTPKQRVTVLGSTGSVGVSTLDVISRHPERFEVFALSAATKVDELLAQCARFLPRFAVM
ASAPHAALLAEKLKQNNLKTVVLMDGDALEKIAAHEEVDAVMAAIVGAAGLGPCLAAARA
GKRLLLANKEALVVGGELFMRTVREGGATLLPIDSEHSAIFQSLPEDPTTWSRRIDKIIL
TASGGPFRTRAPETLGSVTPEQACAHPNWVMGRKISVDSATMMNKALEVIEARHLFGVSP
EQIEVVIHPQSVVHSMVQFTDSSVIAQLGTPDMRVPIAVGLAWPERIESGAARLDFRQMA
SLTFTAPDAALFPGLGLAWHALRAAPGTTAVLNAANEVAVEAFLDRRLRFDRIHAVNMET
LETVSPSKPASLADLLALDASARAAANAAALRFAA