Protein Info for GFF3868 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Tyrosine-protein kinase Wzc (EC 2.7.10.2)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 719 transmembrane" amino acids 31 to 52 (22 residues), see Phobius details amino acids 424 to 448 (25 residues), see Phobius details PF02706: Wzz" amino acids 15 to 106 (92 residues), 78.9 bits, see alignment E=8.7e-26 PF23607: WZC_N" amino acids 110 to 203 (94 residues), 78.7 bits, see alignment E=1.3e-25 PF13807: GNVR" amino acids 366 to 446 (81 residues), 106.7 bits, see alignment E=1.4e-34 TIGR01007: capsular exopolysaccharide family" amino acids 507 to 710 (204 residues), 150.9 bits, see alignment E=1.7e-48 PF01656: CbiA" amino acids 536 to 700 (165 residues), 30.3 bits, see alignment E=1.1e-10 PF13614: AAA_31" amino acids 537 to 650 (114 residues), 43.8 bits, see alignment E=8.2e-15

Best Hits

Swiss-Prot: 100% identical to WZC_SALTY: Tyrosine-protein kinase wzc (wzc) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K00903, protein-tyrosine kinase [EC: 2.7.10.-] (inferred from 91% identity to cko:CKO_00725)

MetaCyc: 88% identical to protein-tyrosine kinase Wzc (Escherichia coli K-12 substr. MG1655)
Receptor protein-tyrosine kinase. [EC: 2.7.10.1, 2.7.10.2, 2.7.10.3, 2.7.12.1]

Predicted SEED Role

"Tyrosine-protein kinase Wzc (EC 2.7.10.2)" in subsystem Colanic acid biosynthesis (EC 2.7.10.2)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.10.- or 2.7.10.1 or 2.7.10.2 or 2.7.10.3 or 2.7.12.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (719 amino acids)

>GFF3868 Tyrosine-protein kinase Wzc (EC 2.7.10.2) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MTEKAKQSAAVTGSDEIDIGRLVGTVIEARWWVLGTTAIFALCAVIYTFFATPIYSADAL
VQIEQNAGNSLVQDINSALANKPPASDAEIQLIRSRLVLGKTVDDLDLDIAVTKNTFPLF
GAGWERLMGRHNEMVKVTTFTRPETMSGQIFTLKVLGDKRYQLVSDGGFSAQGVVGQPLN
KDGVTMRVEAIDARPDTEFTVSKFSTLGMINNLQNNLTVTETGKDTGVLSLTFTGEDRDQ
IREILNSITRNYLQQDIARKSEEAGKSLAFLAKQLPEVRSRLDVAENKLNAFRQDKDSVD
LPLEAKAVLDSMVNIDAQLNELTFKEAEISKLFTKAHPAYRTLLEKRKALEDEKAKLNGR
VTAMPKTQQEIVRLTRDVESGQQVYMQLLNKQQELKITEASTVGDVRIVDPAITQPGVLK
PKKALIILGSIILGLMLSIVGVLLRSLFNRGIESPQALEEHGISVYASIPLSEWQKARDS
VKTIKGIKRYKQSQLLAVGNPTDLAIEAIRSLRTSLHFAMMQAQNNVLMLTGVSPSIGKT
FVCANLAAVISQTHKRVLLIDCDMRKGYTHELLGTNNVDGLSDILAGKGEIASCAKPTAI
ANFDLIPRGQVPPNPSELLMSERFGELIAWASSRYDLVLIDTPPILAVTDAAIVGRHAGT
TLMVARYAVNTLKEVETSLSRFDQNGIQVKGVILNSIFRRATGYQDYGYYEYEYQSDSK