Protein Info for GFF385 in Methylophilus sp. DMC18

Annotation: Transcriptional regulatory protein CpxR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 226 PF00072: Response_reg" amino acids 5 to 113 (109 residues), 104 bits, see alignment E=5.2e-34

Best Hits

Swiss-Prot: 44% identical to CPXR_SHIFL: Transcriptional regulatory protein CpxR (cpxR) from Shigella flexneri

KEGG orthology group: K07662, two-component system, OmpR family, response regulator CpxR (inferred from 60% identity to meh:M301_1021)

MetaCyc: 44% identical to DNA-binding transcriptional dual regulator CpxR (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (226 amino acids)

>GFF385 Transcriptional regulatory protein CpxR (Methylophilus sp. DMC18)
MSKLLLIDDDVELANMLKEFLTQEGYTVTTAHDGLTGEQYVLAGKFDLAILDVMMPGQDG
LQTLRNIRQHSDIPVLMLTAKDDNEGRIEGLEAGADDYVQKPCLPRELVARVRAILRRHT
SDSPKGNDIVVGQLVVSSERRKVFWADKPIIFTSTEFSLIEILAKHAGTIVSKEDLSVKA
LGRPLVKYDRSIDVHLSSIRQKISEVSGGVNVIQTIYRVGYQLVRE