Protein Info for GFF3841 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: RND efflux system, outer membrane lipoprotein CmeC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 496 transmembrane" amino acids 21 to 39 (19 residues), see Phobius details TIGR01845: efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family" amino acids 27 to 492 (466 residues), 385.3 bits, see alignment E=2e-119 PF02321: OEP" amino acids 83 to 264 (182 residues), 116.7 bits, see alignment E=5.5e-38 amino acids 307 to 491 (185 residues), 170.7 bits, see alignment E=1.5e-54

Best Hits

Predicted SEED Role

"RND efflux system, outer membrane lipoprotein CmeC" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (496 amino acids)

>GFF3841 RND efflux system, outer membrane lipoprotein CmeC (Hydrogenophaga sp. GW460-11-11-14-LB1)
VRPGEASSADALDVSPRRWRAIGLTLLAAAALSACSFIPKYERPEAPVASQFPGPQPAAA
ADAKTGADVAWREFIGDAKLRELIALALKNNRDLRVATLNIEQVRAQYQIRRADQFPTIG
LAATGNRQPDGNGGIQSTYSVGLALSTWEIDFFGRLGALKEAALAQYLASEEARHAAQTS
LVAAVASTWLSLQANDELLVLTERTVATREDSLRLSKLRFDNGATSALDLRQAESLTAAA
QSALAQQRRLRALDINALTLLVGQAPPAELLPVPPTLPAPSANANQVVVPTAPVPAATML
REVPAGLPSDLLTRRPDIRQAEQQLIAANANIGAARAAFFPRISLTASAGTASSSLSGLF
KDGSWGFTLAPQALLPIFDAGRNRANLDSSNAGRDIAVAQYEKAIQTAFREVADALAGSA
TLGDQLSAQQLQATAEAERFRLAELRYRNGVASFLDVLDAQRSLFATQQALAQTRLAQQQ
NQVNLYKALGGGWSGQ