Protein Info for GFF3840 in Xanthobacter sp. DMC5

Annotation: Thiol:disulfide interchange protein TlpA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 266 transmembrane" amino acids 34 to 56 (23 residues), see Phobius details PF08534: Redoxin" amino acids 115 to 243 (129 residues), 72.1 bits, see alignment E=8.8e-24 PF00578: AhpC-TSA" amino acids 116 to 230 (115 residues), 62 bits, see alignment E=1.1e-20 PF13905: Thioredoxin_8" amino acids 136 to 230 (95 residues), 40.6 bits, see alignment E=5.2e-14 PF00085: Thioredoxin" amino acids 137 to 180 (44 residues), 24.1 bits, see alignment 6e-09

Best Hits

KEGG orthology group: None (inferred from 64% identity to azc:AZC_4663)

Predicted SEED Role

"Thiol:disulfide oxidoreductase TlpA" in subsystem Biogenesis of c-type cytochromes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (266 amino acids)

>GFF3840 Thiol:disulfide interchange protein TlpA (Xanthobacter sp. DMC5)
MTTADDNRATDPQDTATGPAPGAPVARRSSTVRTIGVVALATLAGAVAGALALYGMNRLP
GNAPQGQSVASVPAAAPSGAAGDPACAGTVERVRAFAPLAKGELAALALASEPRRLPPLT
FTDASGKPVTLADFKGRVVLLNLWATWCVPCRKEMPALDHLEKRLGGPDFAVVAVNLDTR
DPDKPRAFLSEIGVNSLAFYADPATKTFQALRGVGRGFGLPTTLLVDRDGCEMAYLAGPA
EWGGADAEALVKAAIGAGRADAAGSR