Protein Info for GFF3840 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: RND efflux system, inner membrane transporter CmeB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1054 signal peptide" amino acids 10 to 11 (2 residues), see Phobius details transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 340 to 359 (20 residues), see Phobius details amino acids 366 to 387 (22 residues), see Phobius details amino acids 393 to 413 (21 residues), see Phobius details amino acids 438 to 460 (23 residues), see Phobius details amino acids 471 to 496 (26 residues), see Phobius details amino acids 541 to 558 (18 residues), see Phobius details amino acids 870 to 888 (19 residues), see Phobius details amino acids 895 to 915 (21 residues), see Phobius details amino acids 921 to 944 (24 residues), see Phobius details amino acids 970 to 990 (21 residues), see Phobius details amino acids 1002 to 1027 (26 residues), see Phobius details PF00873: ACR_tran" amino acids 1 to 1025 (1025 residues), 1214.4 bits, see alignment E=0 TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1041 (1041 residues), 1584.6 bits, see alignment E=0

Best Hits

Swiss-Prot: 55% identical to ACRF_ECOLI: Multidrug export protein AcrF (acrF) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 76% identity to adk:Alide2_0399)

MetaCyc: 55% identical to multidrug efflux pump RND permease AcrF (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-352; TRANS-RXN-354; TRANS-RXN-355; TRANS-RXN-367

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1054 amino acids)

>GFF3840 RND efflux system, inner membrane transporter CmeB (Hydrogenophaga sp. GW460-11-11-14-LB1)
MAKFFIDRPIFAWVIALFIMVLGGVSITQLPIAQYPPVAPPAIIINAAYPGASAATLEDS
VLSVIEREMNGAPGLIYMESVAQADGSGSITLSFETGTDEDLAQVDVQNRLSRATPRLPS
AVTQQGVRVDKSRSNFLLFTMLASDDPALDPVALGDYAARSVVPELQRLAGVGQAQLFGS
ERAMRIWIDPAKLLGFNLSAADVNNAIRAQNAQVSAGEIGALPNVGGQSIAATVVVNGQL
GSAEQFGNIVLRASSDGATVRLKDVARIELGGQSYATSARLDGKPAVGIGVQLSPSGNAL
ATADAVRNKMHELERFFPTGMKWSIPYDSSRFVKISISQVAQTLGEAMLLVFLVMFLFLQ
NIRYTIIPTIVVPVALLGTFGALLAMGFSINVLTMFGMVLVIGIVVDDAIVVVENVERIM
SEEGLPPLQATRKAMSQISGAIIGVTVVLISVFVPLAFFAGSVGNIYRQFSAVMGVSIAF
SAFLALSLTPALCATLLKPVEAGHHHEKKGFFGWFNRGFSSTAKRYERGVAALLPRAGRT
LIIYVAIIAAAAVVYMRLPTSFLPNEDQGTMLVNVQLPPGATQERTLDVMKQVEGFILKQ
PEVESMVGVLGFSFSGQGQNAALAFVTLKDWAERTAPGSSAEALAGRAFGALSGIRDAFI
YPLSPPPIPELGASSGFTFRLQDRGGLGRDALLSARNQLLGMASQSKVVTQVRPDGLEDA
PQLQIDIDRDKANALGVGFDVINAAIGTSLGSSYVNDFPNAGRLQRVVVQADAPARMQPE
DLLRLNVVNNKGQAVPLSAFATTKWITGPMQTVRYNGYPSMRISGSAAPGMSTGAAIAEM
EKLAAQLPQGIGYEWTGQTREEKLAGSQALILYGFAILAVFLCLAALYESWTIPLSVILV
VPLGVLGVLLATLLRDYSNDVYFQVGLITIIGLSAKNAILIIEFAKDLQAQGKSVIAAAL
EAAHIRFRPIIMTSMAFTLGVLPLAIASGAGSASQRAIGTGVIGGMLTGTVLAVIFVPIF
FVVVRTLFKGSERQHQRDAEQAAAHHGPGVQIDV