Protein Info for GFF3838 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Transcription repressor of multidrug efflux pump acrAB operon, TetR (AcrR) family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 226 PF00440: TetR_N" amino acids 16 to 62 (47 residues), 68.4 bits, see alignment 5.3e-23 PF08361: TetR_C_2" amino acids 86 to 204 (119 residues), 76.9 bits, see alignment E=2.3e-25 PF13977: TetR_C_6" amino acids 102 to 188 (87 residues), 27.7 bits, see alignment E=3.9e-10

Best Hits

KEGG orthology group: K03577, TetR/AcrR family transcriptional regulator, acrAB operon repressor (inferred from 60% identity to pol:Bpro_2034)

Predicted SEED Role

"Transcription repressor of multidrug efflux pump acrAB operon, TetR (AcrR) family" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (226 amino acids)

>GFF3838 Transcription repressor of multidrug efflux pump acrAB operon, TetR (AcrR) family (Hydrogenophaga sp. GW460-11-11-14-LB1)
MVRRTKADALATRHSLLDAAEHLFQERGVSRTSLNDIATAAGTTRGAIYWHFKDKADLFN
AMMERVTMPLEGTLACSARSADTTANPLLSLRDSMMSALKQTATDEQTRRVFEVATHKVE
YVSEMQAVRDRHLQVRNECMVMTEEILQQAVQREGIQLQVPLATAALGLHVIMDGLIQNW
LLDPQAFDLVKSGLDTMDVYLAGLGFTPPVAQALEHPESPRKLAPA