Protein Info for GFF3831 in Xanthobacter sp. DMC5

Annotation: 7-cyano-7-deazaguanine synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 238 PF06508: QueC" amino acids 12 to 235 (224 residues), 236 bits, see alignment E=1.6e-74 TIGR00364: queuosine biosynthesis protein QueC" amino acids 12 to 228 (217 residues), 204.4 bits, see alignment E=6.7e-65

Best Hits

Swiss-Prot: 80% identical to QUEC_AZOC5: 7-cyano-7-deazaguanine synthase (queC) from Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)

KEGG orthology group: K06920, queuosine biosynthesis protein QueC (inferred from 87% identity to xau:Xaut_1874)

Predicted SEED Role

"Queuosine Biosynthesis QueC ATPase" in subsystem Queuosine-Archaeosine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (238 amino acids)

>GFF3831 7-cyano-7-deazaguanine synthase (Xanthobacter sp. DMC5)
MAEAALHREEGALVLFSGGQDSATCLAYALERFGRVETLGFDYGQRHAVELERRPVLRAA
FRALNPLWAARLGDDHVLDLPVLGQISDTALTRDVAVHMEANGLPNTFVPGRNLVFLTFA
AALAYRRGLRHIVGGMCETDFSGYPDCRDDTIKAMQVALNLGMEKRFVLHTPLMWIDKAE
TWRLAEHLGGRPLVELIVEETHTCYLGDRGHRHAWGYGCGECPACRLRADGFARYRAG