Protein Info for GFF3787 in Variovorax sp. SCN45

Annotation: Biotin carboxylase (EC 6.3.4.14)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1097 PF00289: Biotin_carb_N" amino acids 2 to 108 (107 residues), 137 bits, see alignment E=9.2e-44 PF02786: CPSase_L_D2" amino acids 114 to 326 (213 residues), 192.9 bits, see alignment E=1.3e-60 PF02785: Biotin_carb_C" amino acids 343 to 453 (111 residues), 103 bits, see alignment E=2.5e-33 PF00364: Biotin_lipoyl" amino acids 492 to 557 (66 residues), 39.7 bits, see alignment 8.6e-14 PF01039: Carboxyl_trans" amino acids 605 to 1083 (479 residues), 246.2 bits, see alignment E=1.6e-76

Best Hits

KEGG orthology group: None (inferred from 70% identity to dac:Daci_1073)

Predicted SEED Role

"Biotin carboxylase (EC 6.3.4.14)" (EC 6.3.4.14)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.3.4.14

Use Curated BLAST to search for 6.3.4.14

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1097 amino acids)

>GFF3787 Biotin carboxylase (EC 6.3.4.14) (Variovorax sp. SCN45)
LFSKVLIANRGEIAVRLVRALRDLGVASVAVHARDDAAALHAQLADVAVALDATGPSAYL
DIDALIAVAKAQACDAVHPGYGFLSERADFAQACADAGLVFIGPTPQQLGLFGDKARARA
LATQCDVPVMPGSAGAVTLAQAQAFFAEQHAQGAGVMVKAIGGGGGRGMRAVLDAQELPQ
AHARCMSEAKAAFGIEGVYVERLMRNARHIEVQVLGDGKAVASLGERECTLQRRFQKLVE
IAPSPSLPEALRAQVTQAALRMAKTVGYRGLGTFEFLVDAQSSTLPFVFIEANPRLQVEH
TVTEAVTGLDLVQLQIAVAAGETLSALGVEADRTASQRGFALQWRINAETLDAQGNARPS
GGTLARFDLPAGPGVRVDTHGYAGLAPSPHYDTLLAKLIVHSPSPRFADALRRSLRALDE
CHIEGIATNLSLLRAIAARPEFATQAVHTRFVEAHLGDLLASAVSFEKQAKKTVAAPVQE
AALADDGADELTVKAPMPARLVQFEVAVGDVLPAGAQLGVLEAMKMEHLLHAPVAGRVVA
LLAAPGDYLVEGQSLLQLEAVDAQAVEAEARAEHDLDAVRPDLQKVIDRHAPTLDINRKA
AVDKRHAQGGRTARENIADLCDTASDPGNFIEYGALAIAAQTRRRTLEDLIANTPADGMV
TGLGSINAKQFGPEASRCAVLAYDYTVLAGTQGMRNHHKTDRLLAVAHQLKLPVVLFAEG
GGGRPGDTDMPIVAGLNNHTFSQFAALSGKVPVVGIVHGRCFAGNAALLGCADVIIATKG
SNIGMSGPAMIEGGGLGTFAPEQIGPSSVQSRNGVIDILVDDEAAAVAAAKQYLSYFQGA
TTDWQCADPRTLRHVVPENRLRVYDVRAAMRGVADTGSLLELRAGFGAGIVTALARIEGR
PVGLMANNPHHLGGAIDVEAADKSARFMQLCNAHGLPIVSLCDTPGFMVGPEIEAQAQVR
HVCRMFMVASHLRVPFFAVVLRKGYGLGAQAMTAGGFDAPVFTVAWPTGEFGAMGLEGAV
RLGFRKELAAVPEGAERDALFKKLVAQQYANGEAIHMAQTLEIDAVIDPADTRTWLVRGL
DSAGRRHEAVSPYVDTW