Protein Info for GFF3772 in Variovorax sp. SCN45

Annotation: Arginase (EC 3.5.3.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00491: Arginase
  • amino acids 9 to 299 (291 residues), 249.8 bits, E=1.9e-78
• TIGR01229: arginase
  • amino acids 10 to 303 (294 residues), 283.1 bits, E=1.3e-88

Best Hits

KEGG orthology group: K01476, arginase [EC: 3.5.3.1] (inferred from 93% identity to vap:Vapar_4803)

Predicted SEED Role

"Arginase (EC 3.5.3.1)" in subsystem Arginine and Ornithine Degradation (EC 3.5.3.1)

MetaCyc Pathways

• superpathway of arginine and polyamine biosynthesis (15/17 steps found)
• L-arginine degradation VII (arginase 3 pathway) (2/2 steps found)
• putrescine biosynthesis III (2/2 steps found)
• urea cycle (4/5 steps found)
• L-citrulline biosynthesis (6/8 steps found)
• superpathway of polyamine biosynthesis I (6/8 steps found)
• superpathway of polyamine biosynthesis II (6/8 steps found)
• L-arginine degradation VI (arginase 2 pathway) (3/4 steps found)
• superpathway of putrescine biosynthesis (3/4 steps found)
• L-arginine degradation I (arginase pathway) (2/3 steps found)
• L-canavanine degradation I (1/2 steps found)
• superpathway of L-citrulline metabolism (8/12 steps found)
• L-N^δ-acetylornithine biosynthesis (4/7 steps found)
• superpathway of hyoscyamine (atropine) and scopolamine biosynthesis (4/16 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.3.1

Protein Sequence (306 amino acids)

>GFF3772 Arginase (EC 3.5.3.1) (Variovorax sp. SCN45)
MTDHTTTLELIGAPTDVGASVRGAGMGPDALRVAGLPEALAKQGFAVIDRGNLAGPATPW
APPANGLRHLDEVVAWNRSVYAAIDGALGAGHVPLMMGGDHCLAIGSISAVAWHARKRGK
KLRVLWLDAHSDVNTETTSPSGNLHGMPVSCLLGHGPSVLTGWSGERAALAHEAIRFIGI
RSVDSDEKEAIRTLGLSVFDMRHIDEHGMRTTMTEALQDVDEDTHLHVSFDLDCLDPGIA
PGVGTGVRGGPTYREMQLCMEMIADTGRLGSLDVVELNPALDVRNQTAEVAVELIESLFG
KSTLVR