Protein Info for GFF3713 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Xanthine dehydrogenase iron-sulfur subunit (EC 1.17.1.4)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00111: Fer2
  • amino acids 9 to 62 (54 residues), 32.6 bits, E=6.5e-12
• PF01799: Fer2_2
  • amino acids 76 to 148 (73 residues), 107.1 bits, E=4e-35

Best Hits

Swiss-Prot: 53% identical to DCMS_OLICO: Carbon monoxide dehydrogenase small chain (coxS) from Oligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)

KEGG orthology group: K03518, carbon-monoxide dehydrogenase small subunit [EC: 1.2.99.2] (inferred from 78% identity to reh:H16_B0745)

MetaCyc: 50% identical to 1-testosterone hydratase/dehydrogenase gamma subunit (Steroidobacter denitrificans)
RXN-21494 [EC: 1.17.99.11]; 1.17.99.11 [EC: 1.17.99.11]; 1.17.99.11 [EC: 1.17.99.11]

Predicted SEED Role

"Xanthine dehydrogenase iron-sulfur subunit (EC 1.17.1.4)" in subsystem Purine Utilization (EC 1.17.1.4)

MetaCyc Pathways

• adenosine nucleotides degradation II (5/5 steps found)
• purine nucleotides degradation I (plants) (10/12 steps found)
• adenosine nucleotides degradation I (7/8 steps found)
• guanosine nucleotides degradation II (4/4 steps found)
• purine nucleotides degradation II (aerobic) (9/11 steps found)
• superpathway of guanosine nucleotides degradation (plants) (5/6 steps found)
• guanosine nucleotides degradation I (3/4 steps found)
• guanosine nucleotides degradation III (3/4 steps found)
• inosine 5'-phosphate degradation (3/4 steps found)
• ureide biosynthesis (5/7 steps found)
• superpathway of purines degradation in plants (12/18 steps found)
• purine nucleobases degradation II (anaerobic) (15/24 steps found)
• caffeine degradation III (bacteria, via demethylation) (1/7 steps found)
• theophylline degradation (1/9 steps found)
• caffeine degradation IV (bacteria, via demethylation and oxidation) (1/10 steps found)
• androstenedione degradation II (anaerobic) (4/27 steps found)
• superpathway of cholesterol degradation III (oxidase) (5/49 steps found)

KEGG Metabolic Maps

• Methane metabolism
• Purine metabolism
• Trinitrotoluene degradation

Isozymes

Compare fitness of predicted isozymes for: 1.17.1.4, 1.2.99.2

Use Curated BLAST to search for 1.17.1.4 or 1.17.99.11 or 1.2.99.2

Protein Sequence (158 amino acids)

>GFF3713 Xanthine dehydrogenase iron-sulfur subunit (EC 1.17.1.4) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MSQHPINLTVNGEAVQSTVPARRLLSDFLRDDLHLTGTKRGCETGICGACSVLVDGQVVK
SCLSLAVQHNGRSVTTVEGLSQGDTLHPLQESFMQCGGLQCGYCTPGFLMTSCAMLAANP
SPSEDEVRHGLNGNLCRCTGYTQIVESILTAAEKMRGN