Protein Info for GFF3711 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01315: Ald_Xan_dh_C
  • amino acids 25 to 129 (105 residues), 114.6 bits, E=4.2e-37
• PF02738: MoCoBD_1
  • amino acids 146 to 388 (243 residues), 234.9 bits, E=1.2e-73
• PF20256: MoCoBD_2
  • amino acids 413 to 697 (285 residues), 251.8 bits, E=1.4e-78

Best Hits

KEGG orthology group: None (inferred from 78% identity to del:DelCs14_2871)

Predicted SEED Role

"Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4)" in subsystem Purine Utilization (EC 1.17.1.4)

MetaCyc Pathways

• adenosine nucleotides degradation II (5/5 steps found)
• purine nucleotides degradation I (plants) (10/12 steps found)
• adenosine nucleotides degradation I (7/8 steps found)
• guanosine nucleotides degradation II (4/4 steps found)
• purine nucleotides degradation II (aerobic) (9/11 steps found)
• superpathway of guanosine nucleotides degradation (plants) (5/6 steps found)
• guanosine nucleotides degradation I (3/4 steps found)
• guanosine nucleotides degradation III (3/4 steps found)
• inosine 5'-phosphate degradation (3/4 steps found)
• ureide biosynthesis (5/7 steps found)
• superpathway of purines degradation in plants (12/18 steps found)
• purine nucleobases degradation II (anaerobic) (15/24 steps found)
• caffeine degradation III (bacteria, via demethylation) (1/7 steps found)
• theophylline degradation (1/9 steps found)
• caffeine degradation IV (bacteria, via demethylation and oxidation) (1/10 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.17.1.4

Use Curated BLAST to search for 1.17.1.4

Protein Sequence (765 amino acids)

>GFF3711 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MSAAASESTLGRDTPQVNARAKVLGRAVYAGDIKVAGMLHGKILRSPYPHARIVSVDTSA
ALALPGVKAVLTGADAPRTMWGVHQKERRILADGVVRFAGEEVAAVAATTEEIARDALDL
IRIEYEELPALLTPEDALAEGAPGVHPGRGNVAHEIRFERGSVEAGFAQADLIHEATYTT
HAQYPGYLEPMASVAALDPDGRLQVWTSTQSVFLARARLAAALELPVSRVRVVAATVGGG
FGGKIVEDDNQLVAGLLALRTGRAVRLVNNRLEDFQAACSSVPERITLKLGMTREGLIVA
KDVHIVADCGAYCGLSPEVMHVSAMRSDNMHRLQHVRSHATMAYTHTPPHGAFRGFGGTQ
MLFALNSHIHTMAEQLGLDPVEIHRRNAIGRGETSIHGWQIGSTGLLECIAQCTEAIGWR
EKRTRAPGTGSRRRGVGMAAAMHVSGNRTIGNWDGSTVVIKVNEDGRVVVHSSEGDMGQG
AMTMLSQIVAHELCLPLAHVHVIAPDTDTAPFCIGTLASRVTMAAGNAAIVAANAARDKL
LAMAAQMLDAPADQLELAEGHIRVRQQPGQRRTLAEVARQHIWRHGGEGIQVMGSWDAKT
QMHDDQVYGNIAPAYSFAAQAVEVEVDTQTGQVTVIDSYVSDDCGKALNPLAIHGQTNGA
TVQAMGWTLYEHLQLEGGRLMNGNFADYNMPTADAVPMLRGGLVESHEPNGPHGAKGASE
TAILPGAPAIANAVYDAVGVRITDLPITPQKVLAALRALKETAHA