Protein Info for GFF3677 in Xanthobacter sp. DMC5

Annotation: C4-dicarboxylate transport protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 453 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details amino acids 58 to 78 (21 residues), see Phobius details amino acids 90 to 112 (23 residues), see Phobius details amino acids 163 to 185 (23 residues), see Phobius details amino acids 198 to 222 (25 residues), see Phobius details amino acids 232 to 255 (24 residues), see Phobius details amino acids 274 to 289 (16 residues), see Phobius details amino acids 319 to 339 (21 residues), see Phobius details amino acids 344 to 388 (45 residues), see Phobius details PF00375: SDF" amino acids 22 to 414 (393 residues), 376 bits, see alignment E=1.1e-116

Best Hits

Swiss-Prot: 81% identical to DCTA_AZOC5: C4-dicarboxylate transport protein (dctA) from Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)

KEGG orthology group: K11103, aerobic C4-dicarboxylate transport protein (inferred from 87% identity to xau:Xaut_1774)

MetaCyc: 63% identical to C4 dicarboxylate/orotate:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-121; TRANS-RXN-121A; TRANS-RXN-121C; TRANS-RXN-122A; TRANS-RXN0-451; TRANS-RXN0-517; TRANS-RXN0-553

Predicted SEED Role

"C4-dicarboxylate transport protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (453 amino acids)

>GFF3677 C4-dicarboxylate transport protein (Xanthobacter sp. DMC5)
MAHAIPAHPAPHHYPRKFYHHLYFQVIVAIIAGSLLGHFYPDFGASLKPLGDAFIKLVKM
VIAPVIFLTVVTGIAGMRDMGKVGRVAGKAMIYFLTFSTLALVIGLIVANVVQPGAGLNI
DPKTLDPKAVATYAAKAHDASIIGFLMDIIPATPVSAMANGDILQVLFFAVLFGIALGGV
GDLGTPVLKVLTAASHAMFRLVAIVMKAAPIGAFGAMAFTIGKYGIGSVKNLAFLIATFY
LTAALFVFIVLGLVARYNGFSLWKLLRYIREELLLVLGTSSSEAALPGLMLKMERAGCAK
SVVGLVIPTGYSFNLDGTNIYMTLAALFIAQATGIHLSLEEQVLLLLVAMLSSKGAAGIT
GAGFITLAATLSVVPSVPVAGLALILGIDRFMSECRALTNFVGNAVATIVVARWEGELDK
AKLLRVLDGEPISLEDEFDEGLISTAPGVKAVA