Protein Info for GFF3588 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Imidazolonepropionase (EC 3.5.2.7)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01224: imidazolonepropionase
  • amino acids 27 to 401 (375 residues), 453.8 bits, E=2.1e-140
• PF01979: Amidohydro_1
  • amino acids 64 to 402 (339 residues), 67.6 bits, E=1.2e-22
• PF07969: Amidohydro_3
  • amino acids 114 to 378 (265 residues), 39.3 bits, E=6.1e-14

Best Hits

Swiss-Prot: 67% identical to HUTI_POLSJ: Imidazolonepropionase (hutI) from Polaromonas sp. (strain JS666 / ATCC BAA-500)

KEGG orthology group: K01468, imidazolonepropionase [EC: 3.5.2.7] (inferred from 66% identity to ect:ECIAI39_0691)

MetaCyc: 61% identical to imidazolonepropionase (Pseudomonas fluorescens)
Imidazolonepropionase. [EC: 3.5.2.7]

Predicted SEED Role

"Imidazolonepropionase (EC 3.5.2.7)" in subsystem Histidine Degradation (EC 3.5.2.7)

MetaCyc Pathways

• L-histidine degradation VI (7/8 steps found)
• L-histidine degradation I (4/4 steps found)
• L-histidine degradation II (4/5 steps found)
• L-histidine degradation III (4/6 steps found)

KEGG Metabolic Maps

• Histidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.2.7

Protein Sequence (413 amino acids)

>GFF3588 Imidazolonepropionase (EC 3.5.2.7) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MTATTLWRNARLATLDPNQGSDGWGLIEQGALLTDGGRIAWVGALADLPAQARPGREMDL
GGALVTPGLVDCHTHLVYGGQRAAEFEQRLTGVSYEAIARAGGGIRSSVAATRAASEAQL
LASARERARCLMAEGVTTLEIKSGYGLSLEAEARCLRVARRLGAELPLTVRTTFLGAHAV
PPEFDGQPNRYIDAVCDWLPELHAQGLVDAVDAFCERIGFSPAQTRQVFDTAAGLGLPVK
LHAEQLSDQDGAALAASYGALSCDHLEHLSAEGIAAMRAAGTVAVLLPGAYYFLRETRRP
PIEALRAAGVPMAVSTDHNPGTSPGLSLLLMASMACTLFRLTPLEAVQGITVHAARALGL
ADRGRLAADQRADFVAWQLEHPNELAYWFGRNPCHRVVVAGRERTLDGHAAPL