Protein Info for PS417_18185 in Pseudomonas simiae WCS417

Annotation: 5-carboxymethyl-2-hydroxymuconate isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 283 PF01557: FAA_hydrolase" amino acids 75 to 279 (205 residues), 243.6 bits, see alignment E=9.6e-77

Best Hits

KEGG orthology group: None (inferred from 95% identity to pfs:PFLU4108)

MetaCyc: 46% identical to DntG (Burkholderia cepacia R34)
5.3.2.-; 3.7.1.-

Predicted SEED Role

"Putative fumarylacetoacetate (FAA) hydrolase" in subsystem Aromatic amino acid degradation

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UHV2 at UniProt or InterPro

Protein Sequence (283 amino acids)

>PS417_18185 5-carboxymethyl-2-hydroxymuconate isomerase (Pseudomonas simiae WCS417)
MKLASFIVHGRTTYGVVEGDQLIDLESVKSTFGADLKQAIAANRLGELTPAVLAPLPRVP
LADVTFLPVIANPGKVLCIGINYATHVRETGRDMPTYPMIFTRFADSQVAHLQPIIRPKV
SHKLDFEGELAVVIGKTARHVNAADALDYVAGYACYNDGSVRDWQKHTLQFVPGKNFPQT
GGFGPWMVTHDEINDPQELELTTRLNGEVMQHTRTSDMIFDVRQLIEYCSTFTELAPGDV
IVSGTTGGVGAFREPPVWMKPGDTVEVEITGIGRLRNSIADEQ