Protein Info for GFF3546 in Variovorax sp. SCN45

Annotation: Chaperone protein HtpG

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 678 PF13589: HATPase_c_3" amino acids 31 to 147 (117 residues), 27.5 bits, see alignment E=2.8e-10 PF00183: HSP90" amino acids 228 to 677 (450 residues), 422.4 bits, see alignment E=3.4e-130

Best Hits

KEGG orthology group: K04079, molecular chaperone HtpG (inferred from 96% identity to vap:Vapar_4976)

Predicted SEED Role

"Chaperone protein HtpG" in subsystem Protein chaperones

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (678 amino acids)

>GFF3546 Chaperone protein HtpG (Variovorax sp. SCN45)
MADSSNTKLPFQAEVAQLLHLVTHALYSNKEIFLRELISNASDACDKLRFEALDHPELYE
GQSELDVRLSFDKAARTITITDKGIGLSRQEAIDNLGTIAKSGTKDFMSKLSGDQKADAQ
LIGQFGVGFYSGFIVADRISVESRRAGLPADQGVRWVSGGAGDFEVADITRAERGTSITL
HLRDDADEYLNAWKLKQIVGKYSDHISLPILMEKEEWKEGENDQPGDMVKTGEWETVNKA
NALWSRPKKDITPEQYEEFYKSISHDYEAPLAWSHNRVEGSTEYTQLLYIPAKAPFDLWN
RDKSAGVKLYVKRVFIMDDAEALLPSYLRFVKGVIDSADLPLNVSRELLQESRDVKAIRE
GSTKRVLGMLEDLAKKQKTGPESGEGKIDVGSGESVPAPEPTEAVTDVVDKNAPTAAETA
AAAADESGKYAKFYAEFGAVLKEGLGEDMGNRERIAKLLRYASTTTDAVSVSFADYKARM
KEGQDAIYYITADTLAAAKNSPQLEVFKKKGIEVLLMTDRVDEWALNYLNEFDGTPLQSV
AKGAVDLGKLQDEAEKKAAEEAAESFKPLLEKLKEALKDKAEDVRVTTRLVDSPACLVVQ
DGGMSTQLARMLKQAGQPAPELKPVLEVNAEHPLVKKLEGSSHFDDLANILFDQALLAEG
GLPADPAAYVRRVNALLV