Protein Info for GFF3546 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Ferrichrome-iron receptor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 736 signal peptide" amino acids 1 to 32 (32 residues), see Phobius details PF07715: Plug" amino acids 64 to 162 (99 residues), 75.8 bits, see alignment E=3.8e-25 TIGR01783: TonB-dependent siderophore receptor" amino acids 66 to 732 (667 residues), 243.1 bits, see alignment E=3.4e-76 PF00593: TonB_dep_Rec" amino acids 257 to 705 (449 residues), 172.3 bits, see alignment E=3.4e-54

Best Hits

KEGG orthology group: K02014, iron complex outermembrane recepter protein (inferred from 74% identity to dac:Daci_1173)

Predicted SEED Role

"Ferrichrome-iron receptor" in subsystem Iron acquisition in Vibrio or Transport of Iron

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (736 amino acids)

>GFF3546 Ferrichrome-iron receptor (Hydrogenophaga sp. GW460-11-11-14-LB1)
MKKPPAFAPSQTVVTWPLAAGLCLAGATAFAQQSATLSTVTVTSTQEAPLKTDAAPSVKF
TAPLVDTPKTVQIINEELLQQTGATSLQDALRSVPGITFGTGEGGNPTGDQPFIRGMDAQ
ASTFVDGMRDIAAGNREVFNLESVEVIKGADSAYAGRGGAGGSVNLTAKKAKNENFIAGS
VGVGTDAYRRGTLDLNRVVGETTGIRLNAMVHEADVAGRNGPENKRWGIAPTVTFGMGTP
TEVSLSWQHLQTNDIPDGGVPYLYSNAAAATLPGGSEVRPTYGTNRENWYGVKARDYQKE
ESDLFTASIQHKFSDTNTFRNTTRQSKSSQDYLWTQPDDSKGNAIKGYVWRRGNARVSEV
NTLQNVSEFSGKAQTGSVGHTYALGLELAKERSAVRSTAVQNNATSNCTAVTMWCASLNN
PDSSVAWSYPYTLPLATVNSIDTTALYGFDTLKLSEQWLVNAGVRADHYKVTAITPTTSL
ASADTLLNYQLGVVFKPAENGSVYASIGTSSRPGGAALGNGNEDLTITTPVLADLDPEKT
RSIEIGTKWDVMDKKLALTAALFRNEVTNVRITENGITYMGGNKVVNGIELGFSGRVMPG
LSVFGGYTFMDSEQTNMGAGNVANGMPFPNTPRHSVSLWTSYNPMPQLTVGFGVYAQSQV
NQGYIRSTVDGGIVTKGQGGYARYDAMVAYQINRNLTAQLNLYNLGDKVYYTGVRSPHYA
NIAAGRSAVASMKFTY