Protein Info for GFF3541 in Sphingobium sp. HT1-2

Annotation: SOS-response repressor and protease LexA (EC 3.4.21.88)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 225 PF01726: LexA_DNA_bind" amino acids 2 to 63 (62 residues), 56.4 bits, see alignment E=2.1e-19 TIGR00498: repressor LexA" amino acids 2 to 224 (223 residues), 170.3 bits, see alignment E=2e-54 PF00717: Peptidase_S24" amino acids 104 to 217 (114 residues), 100.5 bits, see alignment E=4.9e-33

Best Hits

Swiss-Prot: 70% identical to LEXA_SPHWW: LexA repressor (lexA) from Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)

KEGG orthology group: K01356, repressor LexA [EC: 3.4.21.88] (inferred from 87% identity to sjp:SJA_C1-08440)

Predicted SEED Role

"SOS-response repressor and protease LexA (EC 3.4.21.88)" in subsystem DNA repair, bacterial (EC 3.4.21.88)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.88

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (225 amino acids)

>GFF3541 SOS-response repressor and protease LexA (EC 3.4.21.88) (Sphingobium sp. HT1-2)
MLTPKQQELLSFIQTRLEEGGVSPSFEEMKDALDLRSKSGIHRLINALEERGFIRRLPNR
ARALEVLKLPDAMHRAPAPAIPTPKVSAPAVLLPTAANDVIEIPLHGRIAAGVPIEAMES
HTMLSVPAALLGSGDHYALEVSGDSMMEAGILDGDFALIQRTDVAREGQIVVALIDDAEA
TLKYFRREGARVRLDPANAAYEPQIYDPRQVRIQGKLAGLLRRYN