Protein Info for GFF3515 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 39% identical to Y182_METEA: Uncharacterized oxidoreductase MexAM1_META1p0182 (MexAM1_META1p0182) from Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)

KEGG orthology group: None (inferred from 80% identity to dia:Dtpsy_1869)

MetaCyc: 44% identical to NAD(P)+-dependent L-rhamnose 1-dehydrogenase (Azotobacter vinelandii NBRC 102612)
RXN-12158 [EC: 1.1.1.378]; L-rhamnose 1-dehydrogenase. [EC: 1.1.1.378, 1.1.1.173]

Predicted SEED Role

"3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100)" in subsystem Fatty Acid Biosynthesis FASII or mycolic acid synthesis (EC 1.1.1.100)

MetaCyc Pathways

superpathway of fatty acids biosynthesis (E. coli) (48/53 steps found)
superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
palmitate biosynthesis II (type II fatty acid synthase) (29/31 steps found)
oleate biosynthesis IV (anaerobic) (13/14 steps found)
superpathway of unsaturated fatty acids biosynthesis (E. coli) (17/20 steps found)
superpathway of fatty acid biosynthesis I (E. coli) (14/16 steps found)
biotin biosynthesis I (13/15 steps found)
palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) (8/9 steps found)
fatty acid elongation -- saturated (5/5 steps found)
gondoate biosynthesis (anaerobic) (4/4 steps found)
8-amino-7-oxononanoate biosynthesis I (9/11 steps found)
(5Z)-dodecenoate biosynthesis I (5/6 steps found)
stearate biosynthesis II (bacteria and plants) (5/6 steps found)
anteiso-branched-chain fatty acid biosynthesis (25/34 steps found)
even iso-branched-chain fatty acid biosynthesis (25/34 steps found)
odd iso-branched-chain fatty acid biosynthesis (25/34 steps found)
8-amino-7-oxononanoate biosynthesis IV (4/5 steps found)
cis-vaccenate biosynthesis (4/5 steps found)
octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) (9/12 steps found)
palmitate biosynthesis III (21/29 steps found)
(5Z)-dodecenoate biosynthesis II (4/6 steps found)
stearate biosynthesis IV (4/6 steps found)
tetradecanoate biosynthesis (mitochondria) (17/25 steps found)
L-rhamnose degradation III (4/7 steps found)
L-rhamnose degradation II (4/8 steps found)
petroselinate biosynthesis (2/6 steps found)
2-allylmalonyl-CoA biosynthesis (2/8 steps found)
streptorubin B biosynthesis (20/34 steps found)
mycolate biosynthesis (26/205 steps found)
superpathway of mycolate biosynthesis (27/239 steps found)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.100

Use Curated BLAST to search for 1.1.1.100 or 1.1.1.173 or 1.1.1.378

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (263 amino acids)

>GFF3515 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MNTPASSSSVHFGHQGRVVLVTGGSQGIGEACARRFAREGAKLVIADVADAPGRALAREL
GGTYMHCDVGDKADVDAIVAQALATHGRIDVLVNNAGIFKAARFLDVTEDDFDEVLRVNL
KGAFLMGQAVARAMVQQAEGGSIVNMSSVNGVLAIPDIASYNVSKGGINQLTRAMALALA
DHGIRVNAVAPGTIATELAAKAVLTSEEARHKILSRTPLKRLGEPDEIADVVAWLASDAA
SYVTGEIVTVDGGRMALNYTVPV