Protein Info for GFF351 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Xanthine permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 463 transmembrane" amino acids 36 to 62 (27 residues), see Phobius details amino acids 70 to 90 (21 residues), see Phobius details amino acids 128 to 147 (20 residues), see Phobius details amino acids 158 to 182 (25 residues), see Phobius details amino acids 194 to 212 (19 residues), see Phobius details amino acids 219 to 240 (22 residues), see Phobius details amino acids 260 to 280 (21 residues), see Phobius details amino acids 350 to 372 (23 residues), see Phobius details amino acids 379 to 399 (21 residues), see Phobius details amino acids 408 to 427 (20 residues), see Phobius details amino acids 439 to 458 (20 residues), see Phobius details TIGR00801: uracil-xanthine permease" amino acids 29 to 457 (429 residues), 471.2 bits, see alignment E=1.5e-145 PF00860: Xan_ur_permease" amino acids 34 to 427 (394 residues), 375.3 bits, see alignment E=1.5e-116

Best Hits

Swiss-Prot: 95% identical to XANP_SHIFL: Xanthine permease XanP (xanP) from Shigella flexneri

KEGG orthology group: K03458, nucleobase:cation symporter-2, NCS2 family (inferred from 100% identity to seg:SG3685)

MetaCyc: 95% identical to xanthine:H+ symporter XanP (Escherichia coli K-12 substr. MG1655)
RXN-5076

Predicted SEED Role

"Xanthine permease" in subsystem Purine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (463 amino acids)

>GFF351 Xanthine permease (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MSVNAIEPADAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQA
LGLPAQDTQHIISMSLFASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKT
GGADVPTMMAALFGTLMLASCTEMVLSRILHLARRIITPLVSGVVVMIIGLSLIQVGLTS
IGGGYAAMSDNTFGAPKNLLLAGVVLAIIILLNRQRNPYLRVASLVIAMAAGYLLAWFMG
MLPENNAPVSQDILMVPTPLYYGLGIDWNLLLPLMLVFMITSLETIGDITATSDVSEQPV
SGPLYMKRLKGGVLANGLNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLI
VLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVSREPLNRRAILIIALSLAVGL
GVSQQPQILQFAPEWVKNLLSSGIAAGGITAIVLNLILPPEKP