Protein Info for GFF3462 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Acyl-CoA dehydrogenase (EC 1.3.8.7)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 593 PF12418: AcylCoA_DH_N" amino acids 3 to 33 (31 residues), 35.4 bits, see alignment (E = 2.6e-12) PF02771: Acyl-CoA_dh_N" amino acids 78 to 156 (79 residues), 39.3 bits, see alignment E=2.2e-13 PF02770: Acyl-CoA_dh_M" amino acids 162 to 269 (108 residues), 48 bits, see alignment E=3.6e-16 PF00441: Acyl-CoA_dh_1" amino acids 283 to 446 (164 residues), 98.3 bits, see alignment E=1.5e-31 PF08028: Acyl-CoA_dh_2" amino acids 302 to 438 (137 residues), 33 bits, see alignment E=2e-11 PF12806: Acyl-CoA_dh_C" amino acids 471 to 588 (118 residues), 92.5 bits, see alignment E=6.8e-30

Best Hits

KEGG orthology group: None (inferred from 92% identity to rpi:Rpic_2638)

Predicted SEED Role

"Acyl-CoA dehydrogenase (EC 1.3.8.7)" (EC 1.3.8.7)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.3.8.7

Use Curated BLAST to search for 1.3.8.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (593 amino acids)

>GFF3462 Acyl-CoA dehydrogenase (EC 1.3.8.7) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MSTYAAPLRDMLFTIREVGGLDAICAQPGHEETTLDLVEAILQEAAHYATGVLDPLNRTG
DVQGARWHDGQVTSADGFREAWASFCGNGWNGMPAATKWGGQGLPTLVSTAVLEMWKSSN
LAFSLCQMLTLGAVEAIAHHGSDALKRRFLEPMVAGRWTGTMNLTEPQAGSDLAALRSRA
VPEGDHYRVSGNKIFITWGEHDMAENIVHLVLARLPDAPPGVKGISLFLCPKYLVDDDGS
LGEHNDLACTSIEHKMGIHGSPTASMSFGDGGGAIGYLVGEPNQGLACMFTMMNHARLNV
GLEGVGIAERAYQRARAYALERVQGKPLLSGSTTIAGHPDVRRMLMDMKARTEAMRALAY
FCAGQMDRAAGHADAQEREQALALVGLLIPVVKGWCTDSAQGITSDGVQVHGGMGYVEET
GASQHLRDARITTIYEGTTGIQANDLIGRKLAREGGRTLKALLGRIDRDARRLAEMPDAA
LARIGSVLAASAHALEEAADWLLAHDDQPAQCAAGAVPFLRLAGTVIGGWLSARMAEAAT
AQLAARSGDASFLGAKRATASHYAAHVLVQVPMLRDIVTGGAASTLALADDQL