Protein Info for PS417_01760 in Pseudomonas simiae WCS417

Annotation: imidazolonepropionase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01224: imidazolonepropionase
  • amino acids 22 to 396 (375 residues), 486 bits, E=3.4e-150
• PF01979: Amidohydro_1
  • amino acids 57 to 375 (319 residues), 79.4 bits, E=3.1e-26
• PF07969: Amidohydro_3
  • amino acids 104 to 375 (272 residues), 62.9 bits, E=4.1e-21

Best Hits

Swiss-Prot: 87% identical to HUTI_PSEPF: Imidazolonepropionase (hutI) from Pseudomonas fluorescens (strain Pf0-1)

KEGG orthology group: K01468, imidazolonepropionase [EC: 3.5.2.7] (inferred from 97% identity to pfs:PFLU0369)

MetaCyc: 82% identical to imidazolonepropionase (Pseudomonas fluorescens)
Imidazolonepropionase. [EC: 3.5.2.7]

Predicted SEED Role

"Imidazolonepropionase (EC 3.5.2.7)" in subsystem Histidine Degradation (EC 3.5.2.7)

MetaCyc Pathways

• L-histidine degradation II (5/5 steps found)
• L-histidine degradation VI (7/8 steps found)
• L-histidine degradation I (4/4 steps found)
• L-histidine degradation III (4/6 steps found)

KEGG Metabolic Maps

• Histidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.2.7

Sequence Analysis Tools

See A0A1N7U8W6 at UniProt or InterPro

Protein Sequence (401 amino acids)

>PS417_01760 imidazolonepropionase (Pseudomonas simiae WCS417)
MKTLWQHCHVATMAQGNYSIIEDAAMVTAGSLIEWIGPRSQVPTADYAQVHDLQGAWVTP
GLIDCHTHTVFGGNRSGEFEQRLEGVSYAEIAAKGGGIASTVRATRAATEDELFASAHKR
LRSLLRDGVTTVEIKSGYGLDLVNERKMLRVARRLGEALPVSVRATCLAAHALPPEYKDR
ADDYIDHICVEMLPALAAEGLVDAVDAFCEYLAFSTEQVERVFKVAQQLGLPVKLHAEQL
SSLHGSSLAARYQALSADHLEFMTEDDAIAMAASGTVAVLLPGAFYFLRETQLPPMDALR
KHGVKIAIASDLNPGTSPALSVRLMLNMACTLFRMTPEEALAGATQHAATALGMGDTHGS
LEAGKVADFVAWQIDRPADLAYWLGGELDKRVVRHGVDVTV