Protein Info for GFF3427 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01494: FAD_binding_3
  • amino acids 21 to 52 (32 residues), 22 bits, see alignment (E = 3.9e-08)
• PF00890: FAD_binding_2
  • amino acids 23 to 229 (207 residues), 61.8 bits, E=3.3e-20
• PF07992: Pyr_redox_2
  • amino acids 23 to 58 (36 residues), 28.2 bits, 5.8e-10
• PF01266: DAO
  • amino acids 23 to 88 (66 residues), 38.1 bits, E=6.4e-13
• PF03486: HI0933_like
  • amino acids 23 to 199 (177 residues), 34 bits, E=6.4e-12
• PF01134: GIDA
  • amino acids 23 to 51 (29 residues), 20.3 bits, see alignment (E = 1.2e-07)
• PF12831: FAD_oxidored
  • amino acids 23 to 211 (189 residues), 38.9 bits, E=3.2e-13
• PF02910: Succ_DH_flav_C
  • amino acids 446 to 507 (62 residues), 22.3 bits, E=4.9e-08

Best Hits

KEGG orthology group: None (inferred from 76% identity to vap:Vapar_1895)

Predicted SEED Role

"Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1)" in subsystem Serine-glyoxylate cycle or Succinate dehydrogenase or TCA Cycle (EC 1.3.99.1)

MetaCyc Pathways

• aerobic respiration III (alternative oxidase pathway) (3/3 steps found)
• aerobic respiration I (cytochrome c) (3/4 steps found)
• TCA cycle III (animals) (7/10 steps found)
• succinate to cytochrome bd oxidase electron transfer (1/2 steps found)
• succinate to cytochrome bo oxidase electron transfer (1/2 steps found)
• aerobic respiration II (cytochrome c) (yeast) (2/4 steps found)

KEGG Metabolic Maps

• Benzoate degradation via CoA ligation
• Biosynthesis of phenylpropanoids
• Butanoate metabolism
• Citrate cycle (TCA cycle)
• Oxidative phosphorylation
• Reductive carboxylate cycle (CO2 fixation)

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.1

Use Curated BLAST to search for 1.3.99.1

Protein Sequence (545 amino acids)

>GFF3427 Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MAQHGLSSPLLSDAAGQQQIETDVLVIGGGPAGAWAAVAAAARGARVTLVEKGFCGTSGA
TAPSGTGLWHVPRDAAAREKAKASRYAMGGELAEHAWMDRVLEQTWLNTETLTEWGYPFP
IDTEGQLQRTSLQGPEYMRLMRKKVKESGARILDHSPALELLTDENGDVAGATGITRTTG
ETWVARAGAVVITTGGCAFLSRALGCNVLTGDGYLLGAEVGAELSGMEFSNAYGLGPSFS
SVTKSLFYNWATFYDRDGVAIEGAGSSRGRSVIARTLQTQPVFACLDRADAEIRAWMRNA
QPNFFVSFDRQGIDPFKDHFPVALRLEGTVRGTGGLHVIGDDCATSVPGLYAAGDAATRE
LICGAFTGGGSHNAAWAMSSGFWAGAGAADFSRGARSLVKRRLHRAGTAGIQEGGAPAWD
PEELVRAVQAEVFPYERNWTRRADLLEDSLQRLDAQWARVRHASAPSLQQAVRAREAVAM
LATSRWMYRSALQRTETRGMARRQDHTGLDLGQRHRLVSGGLDEVWVRQQTVRPPANLDL
ERLAA