Protein Info for GFF3374 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to FABD_SALTY: Malonyl CoA-acyl carrier protein transacylase (fabD) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K00645, [acyl-carrier-protein] S-malonyltransferase [EC: 2.3.1.39] (inferred from 99% identity to ses:SARI_01804)

MetaCyc: 94% identical to [acyl-carrier-protein] S-malonyltransferase (Escherichia coli K-12 substr. MG1655)
[Acyl-carrier-protein] S-malonyltransferase. [EC: 2.3.1.39]

Predicted SEED Role

"Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39)" in subsystem Fatty Acid Biosynthesis FASII or mycolic acid synthesis (EC 2.3.1.39)

MetaCyc Pathways

superpathway of fatty acids biosynthesis (E. coli) (51/53 steps found)
superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
superpathway of fatty acid biosynthesis I (E. coli) (16/16 steps found)
superpathway of fatty acid biosynthesis initiation (5/5 steps found)
fatty acid biosynthesis initiation (type II) (3/3 steps found)
fatty acid biosynthesis initiation (mitochondria) (3/4 steps found)
fatty acid biosynthesis initiation (plant mitochondria) (1/4 steps found)
mycobactin biosynthesis (2/11 steps found)
pederin biosynthesis (2/14 steps found)
bryostatin biosynthesis (2/19 steps found)
mupirocin biosynthesis (2/26 steps found)
corallopyronin A biosynthesis (2/30 steps found)

KEGG Metabolic Maps

Fatty acid biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.39

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (309 amino acids)

>GFF3374 Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MTQFAFVFPGQGSQSVGMLAEMAANYPIVEETFAEASAALGYDLWALTQQGPAEELNKTW
QTQPALLTASVALWRVWQQQGGKMPALMAGHSLGEYSALVCAGVINFADAVRLVEMRGKF
MQEAVPEGTGGMSAIIGLDDASIAKACEESAEGQVVSPVNFNSPGQVVIAGHKEAVERAG
AACKAAGAKRALPLPVSVPSHCALMKPAADKLAVELAKITFSAPTVPVVNNVDVKCETDA
AAIRDALVRQLYNPVQWTKSVEFIAAQGVEHLYEVGPGKVLTGLTKRIVDTLTASALNEP
AALSAALTQ