Protein Info for GFF3359 in Hydrogenophaga sp. GW460-11-11-14-LB1
Annotation: Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 72% identical to DHAS_BORPE: Aspartate-semialdehyde dehydrogenase (asd) from Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
KEGG orthology group: K00133, aspartate-semialdehyde dehydrogenase [EC: 1.2.1.11] (inferred from 92% identity to dia:Dtpsy_2588)MetaCyc: 64% identical to aspartate-beta-semialdehyde dehydrogenase subunit (Vibrio cholerae)
Aspartate-semialdehyde dehydrogenase. [EC: 1.2.1.11]
Predicted SEED Role
"Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11)" in subsystem Lysine Biosynthesis DAP Pathway or Threonine and Homoserine Biosynthesis (EC 1.2.1.11)
MetaCyc Pathways
- aspartate superpathway (24/25 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (17/18 steps found)
- superpathway of L-isoleucine biosynthesis I (13/13 steps found)
- L-lysine biosynthesis I (9/9 steps found)
- superpathway of L-methionine biosynthesis (by sulfhydrylation) (11/12 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
- superpathway of L-threonine biosynthesis (6/6 steps found)
- superpathway of S-adenosyl-L-methionine biosynthesis (8/9 steps found)
- superpathway of L-methionine biosynthesis (transsulfuration) (8/9 steps found)
- superpathway of L-homoserine and L-methionine biosynthesis (7/8 steps found)
- L-lysine biosynthesis III (6/7 steps found)
- L-lysine biosynthesis VI (6/7 steps found)
- L-homoserine biosynthesis (3/3 steps found)
- L-lysine biosynthesis II (7/9 steps found)
- dipicolinate biosynthesis (3/4 steps found)
- chorismate biosynthesis II (archaea) (8/12 steps found)
- L-methionine biosynthesis IV (2/4 steps found)
- spermidine biosynthesis II (2/4 steps found)
- ectoine biosynthesis (2/5 steps found)
- 3-dehydroquinate biosynthesis II (archaea) (3/7 steps found)
- norspermidine biosynthesis (2/6 steps found)
- cremeomycin biosynthesis (2/7 steps found)
- grixazone biosynthesis (2/8 steps found)
- superpathway of polyamine biosynthesis III (2/8 steps found)
- platensimycin biosynthesis (6/26 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Biosynthesis of plant hormones
- Glycine, serine and threonine metabolism
- Lysine biosynthesis
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.2.1.11
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (375 amino acids)
>GFF3359 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) (Hydrogenophaga sp. GW460-11-11-14-LB1) MKLVGLVGWRGMVGSVLMDRMVAESDFDLIEPLFFSTSNAGGKAPAMAKNETQLQDAHDI AALKRCDIVITAQGGDYTSEVYPKLRAAGWNGHWIDAASTLRMDKNAVIVLDPVNLPVIQ NALAHGGKDWIGGNCTVSCMLMGVGALYKAGLVEWMSTQTYQAASGGGAQHMRELLTQYG TLNAEVKALLDDPKSAILEIDRKVIAKQRSLSSAETANFGVPLGGSLIPWIDKDLGNGMS KEEWKGMAETNKILGMGEGFHAPAIPVDGFCVRVGAMRCHSQALTFKLKKDVPLADIEAM IAADNAWVKVVPNTREATIQDLTPVAVTGTMTIPVGRLRKLAMGPEYLGAFTIGDQLLWG AAEPLRRMLRILLEA