Protein Info for GFF3358 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Translation initiation factor 2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 893 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details transmembrane" amino acids 483 to 501 (19 residues), see Phobius details TIGR03505: FimV N-terminal domain" amino acids 215 to 286 (72 residues), 72.7 bits, see alignment E=1.6e-24 TIGR03504: FimV C-terminal domain" amino acids 849 to 891 (43 residues), 35.1 bits, see alignment 1e-12

Best Hits

KEGG orthology group: K07288, uncharacterized membrane protein (inferred from 54% identity to dia:Dtpsy_2589)

Predicted SEED Role

"Translation initiation factor 2" in subsystem NusA-TFII Cluster or Translation initiation factors eukaryotic and archaeal or Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (893 amino acids)

>GFF3358 Translation initiation factor 2 (Hydrogenophaga sp. GW460-11-11-14-LB1)
LHAVAAAAVLCASLVHHTDAQALALGRVVVQSALGEPLRAEIDVPDINAEEAASLRVGLA
SGDTFRAAGVDVNSALATLQISLQRRADGRAYLRLTSTRPVTEPFVDLIVEANWSSGRMV
RDYTLLFDPPNLRAAAPQPAPVAPGVSAPAPAAQAPRPAAPAPSAAAPQVQPPRASAPAP
AAPAPAPAPVARPAPAPAPAPANSGGGQVRVQAGDTAGGIAAANKPADVSLDQMLVAMLR
QNPNAFISGNVNRMKAGVVLDLPTAAEAGAIAPGEARQTITAQSRDFNEFRRRLAGSAPE
AGVAAADRQAAGKVQTEVKEAKPAAPAADKLTLSKEGAPGQTAANEEKIAKERQAKEASS
RVAELSRNIEELSKLGGGSAPAPAPAAPAAAPAPAAPAAAAPAPAPAPAAPAVTVPTAPA
PAEAVPAPAAPAAQAPAPAAPPADAPAAAAPSTTPAPVKPPLPVPTPLPDEPSFFDQLRE
NPLALPLAGGLLALLAGLGLYRMRQRKHGSSVDSSFLESRLQPDSFFGSSGGQRIDTAES
VASGSSMVYSPSQLDAAGDVDPVAEADVYLAYGRDLQAEEILKEAMRSTPTRVAIHNKLL
EIYAKRRDARAFEVVATEAYGLTQGQGPEWEHACELGKELDPSNPLYQPGGSPAVKVAAT
AGIAGAGLNTMPFTASTLNEPGKAATPSGLGDLDLDLDFSLDEPSDAAPLSAASAAEAGM
SSMDDLKMTEALTSARVQEKEGPSSSMSMDFDLDFPSGPAPLQEHAPEPAQALDRTPASD
FDALSFDDGPILDLDASHAPNASAPTPPPAAPEMLSFDLNNLNLDLSAPPVEDDATSAGR
LTEENPLETKLSLAEEFRAIGDFEGARSLAEEVLAEASGSLKAKAGTFLADLA