Protein Info for GFF3337 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: 3-oxoacyl-[acyl-carrier-protein] synthase, KASII (EC 2.3.1.179)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03150: beta-ketoacyl-acyl-carrier-protein synthase II
  • amino acids 4 to 412 (409 residues), 655.9 bits, E=1e-201
• PF00109: ketoacyl-synt
  • amino acids 4 to 251 (248 residues), 214.1 bits, E=2.6e-67
• PF02801: Ketoacyl-synt_C
  • amino acids 259 to 371 (113 residues), 127.3 bits, E=3.3e-41

Best Hits

Swiss-Prot: 61% identical to FABF_ECO57: 3-oxoacyl-[acyl-carrier-protein] synthase 2 (fabF) from Escherichia coli O157:H7

KEGG orthology group: None (inferred from 87% identity to hmg:100201105)

MetaCyc: 61% identical to 3-oxoacyl-[acyl carrier protein] synthase 2 (Escherichia coli K-12 substr. MG1655)
Beta-ketoacyl-acyl-carrier-protein synthase II. [EC: 2.3.1.179, 2.3.1.41]; 2.3.1.179,2.3.1.41 [EC: 2.3.1.179, 2.3.1.41]; 2.3.1.179,2.3.1.41 [EC: 2.3.1.179, 2.3.1.41]; 2.3.1.179 [EC: 2.3.1.179, 2.3.1.41]

Predicted SEED Role

"3-oxoacyl-[acyl-carrier-protein] synthase, KASII (EC 2.3.1.179)" (EC 2.3.1.179)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (48/53 steps found)
• superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
• palmitate biosynthesis II (type II fatty acid synthase) (29/31 steps found)
• oleate biosynthesis IV (anaerobic) (13/14 steps found)
• superpathway of unsaturated fatty acids biosynthesis (E. coli) (17/20 steps found)
• superpathway of fatty acid biosynthesis I (E. coli) (14/16 steps found)
• biotin biosynthesis I (13/15 steps found)
• palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) (8/9 steps found)
• fatty acid elongation -- saturated (5/5 steps found)
• gondoate biosynthesis (anaerobic) (4/4 steps found)
• 8-amino-7-oxononanoate biosynthesis I (9/11 steps found)
• (5Z)-dodecenoate biosynthesis I (5/6 steps found)
• stearate biosynthesis II (bacteria and plants) (5/6 steps found)
• anteiso-branched-chain fatty acid biosynthesis (25/34 steps found)
• even iso-branched-chain fatty acid biosynthesis (25/34 steps found)
• odd iso-branched-chain fatty acid biosynthesis (25/34 steps found)
• cis-vaccenate biosynthesis (4/5 steps found)
• superpathway of fatty acid biosynthesis initiation (4/5 steps found)
• octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) (9/12 steps found)
• palmitate biosynthesis III (21/29 steps found)
• (5Z)-dodecenoate biosynthesis II (4/6 steps found)
• stearate biosynthesis IV (4/6 steps found)
• fatty acid biosynthesis initiation (mitochondria) (2/4 steps found)
• tetradecanoate biosynthesis (mitochondria) (17/25 steps found)
• petroselinate biosynthesis (2/6 steps found)
• streptorubin B biosynthesis (20/34 steps found)
• mycolate biosynthesis (26/205 steps found)
• superpathway of mycolate biosynthesis (27/239 steps found)

KEGG Metabolic Maps

• Fatty acid biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.179, 2.3.1.41

Use Curated BLAST to search for 2.3.1.179 or 2.3.1.41

Protein Sequence (414 amino acids)

>GFF3337 3-oxoacyl-[acyl-carrier-protein] synthase, KASII (EC 2.3.1.179) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MSRRRVVVTGLGCISPVGNTVADSWTNLLAGQSGIDFITKFDASNFACKFAGEVKGFNLD
EYITAKEARTMDTFIHYGVAAAMQAVADSGLPTGDQLGEEQATRVGCVIGSGIGGLPLIE
ETHTELTNRGPRRITPFFVPASIINMISGHVSMKFGFKGPNIAIVTACTTGLHCIGEAGR
MIEYGDADVMIAGGSEATVSPLGIGGFXAMRALSTRNDDPKTASRPWDKDRDGFVLGEGA
GVMVLEEYEHAKARGAKIYAELSGFGMSADAGHMTAPNMDGPRRAMLGALRNAGINPDQV
DYLNAHGTSTPLGDINETNAIKAALGDHARNMVVSSTKSMTGHLLGGAGGIESVFTVLSL
HHQKVPPTINIFNQDPECDLDYCANTARDVKIDVAVKNNFGFGGTNGTLVFRRA