Protein Info for GFF3326 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01099: UTP--glucose-1-phosphate uridylyltransferase
  • amino acids 3 to 270 (268 residues), 358.1 bits, E=1.6e-111
• PF00483: NTP_transferase
  • amino acids 10 to 273 (264 residues), 100 bits, E=8.2e-33

Best Hits

Swiss-Prot: 50% identical to GTAB_STAEQ: UTP--glucose-1-phosphate uridylyltransferase (gtaB) from Staphylococcus epidermidis (strain ATCC 35984 / RP62A)

KEGG orthology group: K00963, UTP--glucose-1-phosphate uridylyltransferase [EC: 2.7.7.9] (inferred from 69% identity to adk:Alide2_1638)

MetaCyc: 50% identical to UTP-glucose-1-phosphate uridylyltransferase (Bacillus subtilis subtilis 168)
UTP-monosaccharide-1-phosphate uridylyltransferase. [EC: 2.7.7.64, 2.7.7.9]

Predicted SEED Role

"UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9)" (EC 2.7.7.9)

MetaCyc Pathways

• colanic acid building blocks biosynthesis (10/11 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (5/6 steps found)
• UDP-α-D-glucose biosynthesis (2/2 steps found)
• sucrose biosynthesis I (from photosynthesis) (7/9 steps found)
• superpathway of anaerobic sucrose degradation (14/19 steps found)
• sucrose degradation II (sucrose synthase) (3/5 steps found)
• D-galactose detoxification (1/3 steps found)
• sucrose biosynthesis II (4/8 steps found)
• stachyose degradation (2/7 steps found)
• type I lipoteichoic acid biosynthesis (S. aureus) (5/17 steps found)

KEGG Metabolic Maps

• Galactose metabolism
• Nucleotide sugars metabolism
• Pentose and glucuronate interconversions
• Starch and sucrose metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.7.64 or 2.7.7.9

Protein Sequence (294 amino acids)

>GFF3326 UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MTIRKAVFPVGGLGTRFLPATKAIPKEMLPVVDKPLMQYAVEEAYAAGIREMIFVTGRHK
RAIEDHFDTAYELEMELEAAGKSALLELVHSIKPDDMDCVYVRQPRALGLGHAVLCAERL
VGNEPFAVLLADDLMMGQDQAQGGATVLQQMVQAYESSPGTVLAVQDVPRAETRRYGVVD
VHGANQALAEVFAMVEKPAPDVAPSTLAVAGRYILTPAVFESIRRQPRGAGGEIQLTDGI
AALIGQEKVQAFRYAGKRYDCGSKEGFLEATIDLALANAELSASVRAHLKRLDV