Protein Info for PS417_16930 in Pseudomonas simiae WCS417

Annotation: histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 928 transmembrane" amino acids 24 to 47 (24 residues), see Phobius details amino acids 287 to 311 (25 residues), see Phobius details PF00512: HisKA" amino acids 449 to 514 (66 residues), 66.6 bits, see alignment 2.5e-22 PF02518: HATPase_c" amino acids 561 to 675 (115 residues), 89.3 bits, see alignment E=3.5e-29 PF00072: Response_reg" amino acids 808 to 916 (109 residues), 82.7 bits, see alignment E=3.2e-27

Best Hits

KEGG orthology group: K07677, two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC: 2.7.13.3] (inferred from 80% identity to pfo:Pfl01_3038)

Predicted SEED Role

"sensor histidine kinase/response regulator"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UMT5 at UniProt or InterPro

Protein Sequence (928 amino acids)

>PS417_16930 histidine kinase (Pseudomonas simiae WCS417)
MRLKSYLHQISPVLSTPNAARRLLRIFALVLLVGILGGVYSFLLFTFNNEISQRRSYMSS
AIAEAHTFFTTREAVLESLSLSATRNAKLDLPVSDEEIRLLLGNTPGKQWSIWLTERMRA
FLKSKQLNLLYVSTDAQVLRLYDATPVAADFPAAMLEQLHALKQQKTLQELWLTHATDGH
SQLYIFIRLDERDLNSGWLGLEMDDREVSNALSDHSAGDFTMFNTQGMPLFSNSHRPPPG
QNLPHLRQQDFFGFVGDGWLPEQIVLRKQLKSSDWQLTYSIDLRAVLWALWPQMLGALLF
CLLTISLVCLLTRRLEHRFITPAIHRIQALVESELFSRDVIQTAPVALCVLRRTDGAEVL
KNTLAQQWLGERGAQLGPGWIRQAFDPDAPSLTDYFEAADGRHLYLSCAPTRYKGEDVLL
CAFSDISARTQIEAALEQARQSADAANEAKTLFLATMSHEIRTPLYGVLGTLELLARTRL
DAQQKSYLHAIEGSSATLLQLICDVLDVSKIEAGQLALELSEFCVPTLVQEVVQGYAAAA
HSKGLQLYACLDPQLPRRLIGDASRVRQILNNLLSNAVKFTDSGRVVLRVKKLGREGERV
CLQWQISDTGKGIAPADQAFIFEPFYQSEGNSHVIAGTGLGLPICLRLTHLMNGTLRMVS
EPGLGSSFSLTVPLEQPSGNAPQSLQALAPEIVYVLSPIRELADSLCGWLRRWGARAQVG
LPTSTQLAGHCVLLELMERRLDLPWQGPRVLASNDGAHEPQFNGDGWQVNLNDLDAIQQA
VRHAQNGQVVPPQTRCEARDLRPLHLHILVAEDNVINQLILRDQLEELGCSVELAGDGED
ALARWHEGTFDVVLTDVNMPRLNGYELAEALRRLGCTTPIIGATANALRGEEALCLAAGM
NHCLVKPFTLRALSTVLAPYERATHEAL