Protein Info for GFF3282 in Variovorax sp. SCN45

Annotation: DNA gyrase subunit B (EC 5.99.1.3)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 869 TIGR01059: DNA gyrase, B subunit" amino acids 31 to 869 (839 residues), 933.1 bits, see alignment E=4.2e-285 PF02518: HATPase_c" amino acids 58 to 161 (104 residues), 53.6 bits, see alignment E=8.8e-18 PF00204: DNA_gyraseB" amino acids 263 to 442 (180 residues), 192.8 bits, see alignment E=1e-60 PF01751: Toprim" amino acids 471 to 593 (123 residues), 67.9 bits, see alignment E=2.1e-22 PF21249: GyrB_hook" amino acids 595 to 623 (29 residues), 32.7 bits, see alignment (E = 1.4e-11) PF18053: GyrB_insert" amino acids 635 to 795 (161 residues), 146.4 bits, see alignment E=2.3e-46 PF00986: DNA_gyraseB_C" amino acids 800 to 858 (59 residues), 105.3 bits, see alignment 4.5e-34

Best Hits

KEGG orthology group: K02470, DNA gyrase subunit B [EC: 5.99.1.3] (inferred from 88% identity to aaa:Acav_0003)

Predicted SEED Role

"DNA gyrase subunit B (EC 5.99.1.3)" in subsystem DNA topoisomerases, Type II, ATP-dependent or Resistance to fluoroquinolones (EC 5.99.1.3)

Isozymes

Compare fitness of predicted isozymes for: 5.99.1.3

Use Curated BLAST to search for 5.99.1.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (869 amino acids)

>GFF3282 DNA gyrase subunit B (EC 5.99.1.3) (Variovorax sp. SCN45)
MSAEENKPDVPHTEPVYIPEIETAAAADNSYGEGSITILEGLEAVRKRPGMYIGDTSDGT
GLHHLVFEVVDNSIDEALAGHCDDIVVTIHSDNSISVTDNGRGIPTGVKMDDKHEPKRSA
AEIALTELHAGGKFNQNSYKVSGGLHGVGVSCVNALSVMLRLVVRREGKIHELEFSRGFV
QNRLLETVSGVEVSPMKIIGDTDKRGTEVHFLPDTQIFKENNDFHYEILSKRLRELSFLN
NGVRIRLKDERTGKEDDFSGAGGVRGFVEFINKGKTVLHPNSFYAEGERPADTYGGIPGT
HIGVEVAMQWNSGYNEQVLCFTNNIPQRDGGTHLTGLRAAMTRVINKYIEENEFAKKAKV
EVTGDDMREGLCCVLSVKVPEPKFSSQTKDKLVSSEVRAPVEDIVGKLLTDYLQERPNDA
KIICGKIVEAARAREAARKAREMTRRKGVLDGMGLPGKLADCQEKDPALCEVYLVEGDSA
GGSAKQGRDRKFQAILPLRGKILNVEKARYEKLLTSNEILTMITALGTGIGRAGATTAGG
GADDFNVAKLRYHRIIIMTDADVDGAHIRTLLLTFFYRQMPELVERGHIYIAQPPLYKVK
VGKEEQYLKDGPALDAFLLKVALKDARIETGGASSTTLSGDTLAELARKHQVAEAVIARL
RNFMDAEALRAIADGVALDLDTTPAAEASAVALQAKLRELNTTGVPAEVSSEFDARTDKP
LLRISRRHHGNIKSSVLTQDFVHGADYAALAEAANTFRGLLSPEGALVKRGEGERAKEEK
VDDFRQAMKWLISEAERATSRQRYKGLGEMNPEQLWETTMDPTVRRLLRVQIDDAIEADR
VFTMLMGDEVEPRREFIEQNALRAANIDV